牙周炎相关关键微生物的网络分析构建与预测  

Network analysis and characteristics of keystone taxa in periodontitis

作　　者：邹任杰 吴亚菲[1] 申道南 Zou Renjie;Wu Yafei;Shen Daonan(Department of Periodontology,West China Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院牙周科,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,成都610041

出　　处：《中华口腔医学杂志》2020年第12期1005-1010,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81771077)。

摘　　要：菌斑微生物之间存在复杂的相互作用,在环境因素的影响下可使群落产生重构,促进牙周炎的发生与发展。关键微生物在调节微生物群落动态变化中十分重要。在牙周微生态中,共存网络构建和分析的方法有助于筛选牙周炎相关的关键微生物以便进一步进行实验研究。这些微生物如牙龈卟啉单胞菌等可以作为微生物成员的重要联络者协同调节群落毒力等特征,或作为响应环境因素的重要调控因子如介导免疫失衡推动群落结构和功能重塑。本文将从微生物共存网络构建、应用网络拓扑分析技术进行关键微生物筛选与预测,以及与牙周炎发生发展相关的关键微生物等方面进行综述,为进一步确定关键微生物以及研究此类微生物在群落动态变化中的作用提供参考。Subgingival microorganisms can orchestrate the microbial community under the influence of environmental factors,thus causing the initiation and progression of periodontitis.Keystone taxa play an important role in the dynamic changes of microbial community.The co-occurrence network analysis may pave the way for screening periodontitis associated candidate keystone taxa in the periodontal microflora.These microorganisms,e.g.Porphyromonas gingivalis,might function via myriad of intermediary taxa or as the chokepoint community-remodeling drivers in response of environmental factors.Herein,we review and discuss the construction of microbial co-occurrence network,the way of screening and identifying keystone taxa using network analysis as well as the characteristic of candidate keystone taxa related to periodontitis for the purpose that keystone taxa and the role they played in dynamic succession of microflora could be well investigated.

关 键 词：紫单胞菌 龈 共存网络分析 牙周微生态 龈沟产线菌 

分 类 号：R781.42[医药卫生—口腔医学]