DDX3的病理生理学作用  

Pathophysiological effects of DDX3

作　　者：徐伍 徐瑞 张信琴 林加龙 裴海峰 XU Wu;XU Rui;ZHANG Xinqin;LIN Jialong;PEI Haifeng(School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China;College of Medicine, Southwest Jiaotong University, Chengdu 610031 China;School of Nursing, Chengdu Medical College, Chengdu 610500 China;Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China)

机构地区：[1]成都中医药大学医学与生命科学学院,四川成都611130 [2]西南交通大学医学院,四川成都610031 [3]成都医学院护理学院,四川成都610500 [4]中国人民解放军西部战区总医院心内科,四川成都610083

出　　处：《暨南大学学报（自然科学与医学版）》2021年第1期104-112,共9页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(81970241)。

摘　　要：DEAD-box RNA解旋酶3(DEAD-box RNA helicase 3,DDX3),亦称DEAD-box RNA解旋酶3 X连锁(DEAD-box RNA helicase 3 X-linked,DDX3X),是一种高度保守并依赖ATP的RNA解旋酶,广泛分布于真核生物中,主要定位在细胞核和细胞质发挥生理作用,与RNA剪接和衰变、mRNA输出、转录、翻译相关,进一步参与细胞周期的进展、先天免疫反应、细胞凋亡、癌症发生与抑制、病毒的复制周期等多种重要的细胞生理过程.长期以来,DDX3的基因表达,调控及其功能以及它与疾病的关系一直被关注,尤其是与病毒和癌症的关系更为热点研究.因此,本文主要探讨、总结DDX3的病理生理学作用.DEAD-box RNA helicase 3(DDX3),also known as DEAD-box RNA helicase 3 X-linked(DDX3X),is a highly conserved ATP-dependent RNA helicase.It widely distributes in eukaryotes,and mainly locates in the nucleus and cytoplasm to play physiological roles.It is related to RNA splicing and decay,mRNA output,transcription and translation,thus regulating cell cycle progression,innate immune response,apoptosis,cancer development and inhibition,virus replication cycle and many other important cellular physiological processes.For a long time,the gene expression,regulation and function of DDX3 and its relationship with diseases have been paid close attention to,especially the relationship with viruses and cancer has been the focus of many studies.Therefore,this article mainly reviews the pathophysiological effects of DDX3.

关 键 词：DEAD-box RNA解旋酶3 DEAD-box RNA解旋酶3 X连锁 RNA 肿瘤 病毒 

分 类 号：R363[医药卫生—病理学]