介孔二氧化硅载体在酶蛋白固定化中的应用  

Application of Mesoporous Silica Carriers in Immobilization of Enzyme Proteins

作　　者：董思圳 秦风 贾文敬 李欢 董宛阡 李林 黄建忠 舒正玉 DONG Sizhen;QIN Feng;JIA Wenjing;LI Huan;DONG Wanqian;LI Lin;HUANG Jianzhong;SHU Zhengyu(National and Local United Engineering Research Center for Industrial Microbial Fermentation Technology,College of Life Sciences,Fujian Normal University,Fuzhou 350108,China)

机构地区：[1]福建师范大学生命科学学院工业微生物发酵技术国家地方联合工程研究中心,福建福州350108

出　　处：《化学与生物工程》2021年第1期1-4,共4页Chemistry & Bioengineering

基　　金：国家自然科学基金项目(31370802,31870787);福建省自然科学基金项目(2017J01441)。

摘　　要：介孔二氧化硅材料因制备简单、生物相容性良好、比表面积和孔径可控、表面修饰基团多样等特点,被广泛应用于酶蛋白的固定化。主要综述了介孔二氧化硅对水解酶、氧化还原酶等酶蛋白的固定化效果及其影响固定化效果的因素,展望了介孔二氧化硅在酶蛋白固定化中的应用前景及存在的挑战,为介孔二氧化硅更好地应用于固定化酶制剂的制备奠定基础。Due to possessing the characteristics of the simple preparation,excellent biocompatibility,controllable specific surface area and pore size,and variety of surface modification groups,mesoporous silica is widely used in the immobilization of enzyme proteins.In this paper,we mainly summarize the immobilization effects of mesoporous silica on enzyme proteins,such as hydrolase and oxidation-reduction enzyme,and the factors affecting the immobilization effect.Moreover,we put forward the application prospect and challenges of mesoporous silica in the immobilization of enzyme proteins.The study lays a foundation for the better application of mesoporous silica in the preparation of immobilized enzyme preparations.

关 键 词：介孔二氧化硅 酶蛋白 固定化 生物催化剂 

分 类 号：TQ925.2[轻工技术与工程—发酵工程] Q814.2[生物学—生物工程]