口腔鳞癌Survivin表达的临床意义与PCNA关系研究  

Clinical significance of survivin expression in OSCC and its correlation with PCNA

作　　者：于肖鹏[1] 李晓光[1] 苏庆琪[1] 刘桐 李腾宇 王延秀[2] YU Xiao-peng;LI Xiao-guang;SU Qing-qi;LIU Tong;LI Teng-yu;WANG Yan-xiu(DepartmentofStomatology&DepartmentofPain Medicine,Taian City CentralHospital,Taian 271000,China)

机构地区：[1]山东省泰安市中心医院口腔科,山东271000 [2]山东省泰安市中心医院疼痛科,山东271000

出　　处：《中华老年口腔医学杂志》2020年第6期327-329,345,共4页Chinese Journal of Geriatric Dentistry

基　　金：山东省科学技术发展计划资助项目(项目编号:2011GGH21822);泰安市科技局资助项目(项目编号:2016NS1092)。

摘　　要：目的:探讨分析口腔鳞癌(Oral squamous cell carcinoma,OSCC)Survivin蛋白表达的临床意义和与其细胞增殖指标的相关性。方法:筛选106例OSCC肿瘤手术切除后标本,免疫组化方法检测Survivin蛋白和增殖细胞核抗原(Proliferating Cell Nuclear Antigen,PCNA)表达情况,SPSS17.0软件统计分析。结果:①74例(69.81%)OSCC组织表达Survivin,显著高于正常口腔黏膜组织(P<0.01)。PCNA标记指数(PCNA Label index,PLI)平均值为(55.01±22.02)%。②Survivin的表达与OSCC出现淋巴结转移及病理分级和TNM分期有明显相关性(P<0.01)。③Survivin与PCNA的表达明显相关(P<0.01)。结论:①Survivin蛋白表达量可做为一个OSCC预后效果的有效指标。②Survivin具有促进OSCC细胞增殖的作用。Objective:To study investigate the clinical significance of survivin expression in oral squamous cell carcinoma(OSCC)and its correlation with proliferating cell nuclear antigen(PCNA).Methods:A total of 106 OSCC tumor specimens were screened out,and the expression of survivin protein and Proliferating Cell Nuclear Antigen(PCNA)was detected by immunohistochemical method.SPSS17.0 software statistical analysis was performed.Results:①Positive Survivin were detected in 74(69.81%)patients with OSCC,significantly higher than those in normal oral mucous group(P<0.01).PCNA labelling index(PLI)average value was(55.01±22.02)%.②The expression of survivin was closely related to the degree of tumor differentiation、lymph node metastasis and clinical stage(P<0.01).③There was a significant correlation between Survivin and PCNA expression(P<0.01).Conclusion:The expression of survivin is closely related to the clinicopathological characteristics of OSCC,which can be used as an effective index for the prognosis of OSCC.②Survivin can promote the proliferation of OSCC cells.

关 键 词：SURVIVIN 口腔鳞癌 增殖细胞核抗原 免疫组化 

分 类 号：R782[医药卫生—口腔医学]