Caspase家族在肿瘤细胞焦亡中的研究进展  

Progress on research of caspase family in pyroptosis in cancer

作　　者：姜明霞 祁玲 李燕京[1] Jiang Mingxia;Qi Ling;Li Yanjing(Department of Gastrointestinal Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院消化道肿瘤科,黑龙江哈尔滨150081

出　　处：《肿瘤》2020年第12期872-880,共9页Tumor

基　　金：国家自然科学基金(青年项目)(编号:81602662);吴阶平基金(编号:320.6750.2020-05-17);哈尔滨医科大学附属肿瘤医院科学研究基金(编号:BJQN2018-02)。

摘　　要：细胞焦亡是一种依赖于半胱氨酸天冬氨酸蛋白酶(caspase)家族的促炎性细胞死亡方式,是细胞程序性死亡方式中的一种。目前已知的与细胞焦亡相关的caspase家族成员包括caspase-1、caspase-3、caspase-4、caspase-5、caspase-11和caspase-8。活化的caspase可以切割gasdermin(GSDM)家族蛋白,如GSDMD和GSDME,从而引起细胞焦亡及炎性因子释放。越来越多的研究证明,细胞焦亡虽然可以抑制肿瘤的发生和发展,但其同时引发的炎性反应会促进肿瘤的形成。本文将就caspase调控肿瘤细胞焦亡作一综述,以期为肿瘤治疗提供新的靶点和策略。Pyroptosis as a pro-inflammatory cell death method that relies on the cysteinyl aspartate specific proteinase(caspase)family and is a kind of programmed cell death.The currently known caspase family associated with pyroptosis includes caspase-1,caspase-3,caspase-4,caspase-5,caspase-11 and caspase-8.Activated caspase can cleave gasdermin(GSDM)family proteins,such as GSDMD and GSDME,causing pyroptosis and the release of inflammatory factors.More and more researches have proved that pyroptosis can not only inhibit the occurrence and development of tumors,but also promote the formation of tumors due to the inflammatory reaction.This article will review the regulation of tumor cells pyroptosis which is mediated by caspase,to provide new targets and strategies for tumor therapy.

关 键 词：肿瘤 细胞焦亡 半胱氨酸天冬氨酸蛋白酶 

分 类 号：R739.9[医药卫生—肿瘤]