Preoperative rapid suppression of viral load by elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide regimen in human immunodeficiency virus-positive fracture patients significantly reduces postoperative complications  

作　　者：Rui Ma Qiang Zhang Yao-Shen Zhang Biao Xu Zhi-Wen Tong Chang-Song Zhao Ru-Gang Zhao 

机构地区：[1]Department of Orthopedics,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China [2]Department of Orthopedics,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China [3]No.1 Department of General Surgery,The Fourth People’s Hospital of Qinghai Province,Xining,Qinghai 810000,China

出　　处：《Chinese Medical Journal》2020年第23期2892-2893,共2页中华医学杂志（英文版）

基　　金：This work was supported by the grants from the Capital’s Funds for Health Improvement and Research(No.2018-2-2174);Scientific Research Common Program of the Beijing Municipal Commission of Education(No.KM201810025029);the Beijing Municipal Science&Technology Commission(No.Z191100006619060)。

摘　　要：To the Editor:There are 1.25 million people living with human immunodeficiency virus(HIV)(PLWH)in China,with more than 135,000 newly diagnosed cases in 2018.[1]HIV-positive patients who suffer a fracture have extremely high complication rates following operations,and medical staff frequently experience occupational exposure during the perioperative period.Therefore,surgeons are often worried about operating on HIV-positive patients.To ensure the safety of surgeons and reduce patients’postoperative complications,we attempted to maximally suppress the viral load(VL)prior to operation.Previous studies have shown that PLWH demonstrated high uptake of highly active antiretroviral therapy(HAART)and rapid VL suppression.[2]In recent years,more rapid VL suppression has been observed with newly introduced antiretroviral drugs,for example,a combination of the integrase strand transfer inhibitor(INSTI),in a single-tablet regimen(STR)containing elvitegravir,cobicistat,emtricitabine,and tenofovir alafenamide(E/C/F/TAF)(150/150/200/10 mg).[3]Studies have shown that STRs have more reliable virus suppression success rates than multiple-tablet regimens(MTRs).[4]Generally,patients prefer freely available HAART drugs that are available nationally,containing tenofovir disoproxil fumarate,lamivudine,and efavirenz(TDF/3TC/EFV)(400/300/600 mg).In this study,we compared the preoperative effect of E/C/F/TAF and TDF/3TC/EFV regimens in the treatment for HIV-positive patients to reduce VL and improve the immune function in 7 and 10 days.

关 键 词：patients REGIMEN DRUGS 

分 类 号：R512.91[医药卫生—内科学] R687.3[医药卫生—临床医学]