线粒体介导骨骼肌重塑在运动抵御癌症恶病质中的作用研究进展  

Reserach Development ofMitochondrial-Mediated SkeletalMuscle Remodeling inExerciseAgainst Cancer Cachexia

作　　者：张雪 漆正堂[2] 丁树哲[2] ZHANG Xue;QI Zhengtang;DING Shuzhe(Affiliated Sport Polytechnic,Shanghai University of Sport,Shanghai 200237,China;School of Physical Education of Health,East China Normal University,Shanghai 200241,China)

机构地区：[1]上海体育学院附属体育职业技术学院,上海200237 [2]华东师范大学体育与健康学院,上海200241

出　　处：《上海体育学院学报》2021年第1期78-85,共8页Journal of Shanghai University of Sport

基　　金：上海市体育科技“综合计划”项目(19Z022)。

摘　　要：癌症恶病质是一种复杂的多因素综合征,以进行性体质量下降及肌肉减少为特点,以能量耗损、炎症、肌量流失为主要特征。对线粒体介导骨骼肌重塑在运动抵御癌症恶病质中的作用机制进行综述发现:运动通过PGC-1α、IL-6以及泛素化重塑骨骼肌线粒体功能,加强线粒体生物发生和融合,抑制线粒体分裂与自噬,抵抗恶病质状态下骨骼肌的能量耗损、抑制骨骼肌炎症反应和肌量流失,通过重塑骨骼肌功能进而抵御癌症恶病质的发生发展。Cachexia is a complex multifactorial syndrome accompanied by progressive weight loss and muscle loss,and mainly characterized by energy loss,inflammation and muscle mass loss.A review of the research on the mechanism of mitochondrial-mediated skeletal muscle remodeling in exercise against cancer cachexia finds that exercise can rejuvenate mitochondria by PGC-1α,IL-6 and ubiquitin-proteasome system,and remodel skeletal muscle by up-regulation of mitochondrial biosynthesis and mitochondrial fusion,as well as suppression of mitochondrial fission and mitophagy,and then resist cancer cachexia progression through inhibiting energy loss,inflammation and muscle wasting.

关 键 词：运动 癌症 恶病质 线粒体 骨骼肌 肌萎缩 

分 类 号：G804.5[文化科学—运动人体科学]