血清癌胚抗原、鳞状细胞癌抗原、调节性T细胞水平变化在评估宫颈癌患者术后放疗疗效中的应用  

Application of serum CEA,SCC-Ag and blood Treg in evaluating radiotherapy effect of patients with cervical cancer after operation

作　　者：李安[1] 宋蕊 李思瑾[1] LI An;SONG Rui;LI Si-jin(Department of Gynecology,The First Affiliated Hospital of Guangzhou University of traditional Chinese medicine,Guangzhou 510000,China)

机构地区：[1]广州中医药大学第一附属医院妇科,广东广州510000

出　　处：《实用医院临床杂志》2021年第1期145-148,共4页Practical Journal of Clinical Medicine

摘　　要：目的分析血清癌胚抗原(carcinoembryonic antigen,CEA)、鳞状细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)、调节性T细胞(Treg)在评估宫颈癌患者术后放疗疗效中的应用效果。方法选择2017年3月至2019年2月我院收治的宫颈癌术后患者123例,均给予调强放疗。放疗前后检测血清CEA、SCC-Ag、Treg,根据WHO实体瘤疗效评价标准(RECIST)分为有效组84例、稳定组26例和进展组13例,分析血清CEA、SCC-Ag、Treg与放疗的关系。结果放疗后,宫颈癌患者血清CEA、SCC-Ag、Treg低于放疗前(P<0.01)。血清CEA、SCC-Ag、Treg水平有效组低于稳定组和进展组,稳定组低于进展组(P<0.05);血清CEA、SCC-Ag、Treg下降百分比有效组高于稳定组和进展组,稳定组高于进展组(P<0.01)。血清CEA、SCC-Ag、Treg下降百分比与放疗疗效呈正相关(P<0.05)。结论血清CEA、SCC-Ag、Treg水平变化与宫颈癌术后患者放疗疗效密切相关,可作为评估宫颈癌术后放化疗的有效指标。Objective To analyzed the application effect of serum CEA,SCC-Ag and Treg in evaluating the curative effect of postoperative radiotherapy for patients with cervical cancer.Methods We selected 123 postoperative patients with cervical cancer in our hospital for radiotherapy from March 2017 to February 2019 as study subjects.All patients were given intensity modulated radiotherapy(IMRT).Serum CEA,SCC-Ag and Treg were detected before and after radiotherapy.According to response evaluation criteria in solid tumors(RECIST)of WHO,they were divided into effective group(n=84),stable group(n=26)and progressive group(n=13).The relationship between serum CEA,SCC-Ag and Treg and radiotherapy was analyzed.Results After radiotherapy,serum CEA,SCC-Ag and Treg were lower than that before radiotherapy(P<0.01).The serum CEA,SCC-Ag and Treg in the effective group were lower than those in the stable group and the progressive group and those in the stable group were lower than those in the progressive group(P<0.05).The decline percentage of serum CEA,SCC-Ag and Treg in the effective group was higher than that in stable group and the progressive group and that in the stable group was higher than that in the progressive group(P<0.01).The decline percentage in serum CEA,SCC-Ag,and Treg were positively correlated with radiotherapy effect(P<0.05).Conclusion The changes of serum CEA,SCC-Ag and Treg were correlated with radiotherapy effect in patients with cervical cancer.They can be used as effective indicators to evaluate the postoperative radiotherapy and chemotherapy of cervical cancer.

关 键 词：宫颈癌 癌胚抗原 鳞状细胞癌抗原 调节性T细胞 放疗敏感性 

分 类 号：R737.3[医药卫生—肿瘤]