维生素C辅治肝细胞肝癌化疗及对外周血肿瘤相关因子、循环肿瘤细胞的影响  

The effect of adjuvant therapy of vitamin C in the treatment of hepatocellular carcinoma with chemotherapy and its effect on peripheral blood tumor related factors and circulating tumor cells

作　　者：彭磊[1] 梅琳[1] 刘婷[1] 冯锐 何丽莎 PENG Lei;MEI Lin;LIU Ting;FENG Rui;HE Li-sha(The Second Ward,Department of Internal Medicine,Pengzhou Hospital of Traditional Chinese Medicine,Pengzhou 611930,China;Department of Oncology,Chongqing Haigiya Cancer Hospital,Chongqing 401331 China)

机构地区：[1]四川省彭州市中医医院内科二病区,四川彭州611930 [2]重庆海吉亚肿瘤医院肿瘤内科,重庆401331

出　　处：《实用医院临床杂志》2021年第1期155-158,共4页Practical Journal of Clinical Medicine

摘　　要：目的研究维生素C(Vc)辅治肝细胞肝癌化疗及对外周血肿瘤相关因子、循环肿瘤细胞(CTCs)的影响。方法选取2017年6月至2019年5月我院收治的HCC患者150例,按照随机数字表法分为试验组与对照组各75例,对照组给予肝动脉化疗栓塞(TACE)+阿帕替尼治疗。试验组给予TACE+阿帕替尼+VC治疗。观察两组治疗前后外周血总胆红素(TBIL)、白蛋白(ALB)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)等肝功能指标,外周血甲胎蛋白异质体(AFP-L3)、α-烯醇化酶(α-enolase)、高尔基体蛋白73(GP73)、异常凝血酶原(PIVKA-II)等肿瘤相关因子水平,外周血CTCs及不良反应;结果治疗后,试验外周血TBIL、ALT、γ-GT、AFP-L3、α-enolase、GP73、PIVKA-II及CTCs水平均低于对照组,ALB水平高于对照组,试验组客观缓解率、控制率均高于对照组,差异均有统计学意义(P<0.05)。两组各不良反应发生率比较,差异无统计学意义(P>0.05)。结论VC辅助HCC化疗患者可提高疗效,清除外周血CTCs,降低外周血肿瘤相关因子水平,提高患者肝功能,减轻不良反应,改善患者预后。Objective To investigate the effects of adjuvant therapy of vitamin C(VC)in the treatment of hepatocellular carcinoma(HCC)with chemotherapy and its effect on peripheral blood tumor related factors and circulating tumor cells.Methods One hundred and fifty patients with HCC in our hospital from June 2017 to May 2019 were selected.According to the random number table method,they were divided into experimental group or control group,75 in each group.The control group was given transcatheter arterial chemoembolization(TACE)+Apatinib.The experimental group was given TACE+Apatinib+VC.Liver function index such as total bilirubin(TBIL),albumin(ALB),alanine transaminase(ALT)andγ-glutamyl transpeptidase(γ-GT),tumor related factors such as alpha-fetoprotein heterogeneity(AFP-L3),α-enolase,Golgi protein 73(GP73)and abnormal prothrombin(PIVka-II)as well as CTCs and adverse reaction were observed before and after treatment.Results After treatment,the levels of TBIL,ALT andγ-GT in the experimental group were lower than those in the control group while the levels of ALB in the experimental group were higher than those in the control group(P<0.05).After treatment,the levels of AFP-L3,α-enolase,GP73,PIVKA-II and number of CTCs in the experimental group were lower than those in the control group(P<0.05).The ORR and DCR rates in the experimental group were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion Adjuvant therapy of VC in the treatment of HCC with chemotherapy can improve the curative effect,eliminate the peripheral blood CTCs,reduce the level of tumor related factors in peripheral blood,improve the patients'liver function,reduce the adverse reactions,and improve the prognosis of the patients.

关 键 词：维生素C 肝细胞肝癌 化疗 肿瘤相关因子 循环肿瘤细胞 

分 类 号：R735[医药卫生—肿瘤]