8例成人噬血细胞综合征临床分析  

Clinical Characteristics of Hemophagocytic Syndrome in 8 Adults

作　　者：邹文婷 青胜兰[1] 张娜[1] 阳毅[1] ZOU Wen-ting;QING Sheng-lan;ZHANG Na(Hematology Department,People’s Hospital of Deyang,Deyang,Sichuan,618000,China)

机构地区：[1]德阳市人民医院血液科,四川德阳618000

出　　处：《黑龙江医学》2021年第1期44-46,48,共4页Heilongjiang Medical Journal

摘　　要：目的:分析8例噬血细胞综合征的临床表现及实验室检查特点。方法:回顾性分析2017年1月-2019年6月在德阳市人民医院初步诊断为噬血细胞综合征患者8例临床资料,对患者性别、年龄、临床表现、实验室检查结果及归转情况进行分析。结果:本组8例噬血细胞综合征患者,7男1女,患者平均年龄为(46.13?16.65)岁;临床表现主要以发热(100%)、淋巴结大(50%)、肝脏肿大(50%)等为主;实验室检查结果以血细胞减少(100%)、铁蛋白升高(100%)、乳酸脱氢酶升高(87.5%)、甘油三酯升高(75%)、纤维蛋白原降低(37.5%)、可溶性CD25升高(87.5%)、NK细胞活性降低(75%)。比较肿瘤、感染2组HPS患者初诊时各实验室指标HB、Ferr有统计学意义(P<0.05)。比较EB病毒感染与非EB病毒感染2组HPS患者初诊时各实验室指标WBC、HB、PLT、Ferr、LDH、TG、FBG的差异均无统计学意义(P>0.05)。比较死亡组与生存组2组HPS患者初诊时各实验室指标Ferr有统计学意义(P<0.05)。结论:HPS临床表现错综复杂,病因多种多样;高铁蛋白水平的患者预后不佳。Objective:To analyze the clinical manifestations and laboratory characteristics of 8 cases of hemophagocytic syndrome.Methods:Retrospectively analyzing the clinical data of 8 patients with hemophagocytic syndrome which were initially diagnosed in the hospital from January,2017 to June,2019.Gender,age,clinical manifestations,laboratory examination results and regression were analyzed.Results:There were 8 cases of hemophagocytic syndrome in this group,including 7 male and 1 female,with an average age of(46.13+16.65)years.The main clinical manifestations were fever(100%),lymph node(50%)and hepatomegaly(50%).The results of laboratory examination showed hemocytopenia(100%),ferritin(100%),lactate dehydrogenase(87.5%),triglyceride(75%),fibrinogen(37.5%),soluble CD25(87.5%)and NK cell activity(75%).The laboratory indexes of HB and Ferr at the initial diagnosis of HPS patients in the tumor and infection groups were statistically significant(P<0.05).There were no statistically significant differences in WBC,HB,PLT,Ferr,LDH,TG and FBG between the two groups of HPS patients with EB virus infection and non EB virus infection(P>0.05).There was statistically significant difference in Ferr at the initial diagnosis of HPS patients in the death group and survival group(P<0.05).Conclusion:The clinical manifestations and etiology of HPS are complex.Patients with high ferritin levels have poor prognosis.

关 键 词：噬血细胞综合征 病因 临床表现 实验室检查 

分 类 号：R781.62[医药卫生—口腔医学]