幽门螺杆菌通过胃癌干细胞诱导胃癌发生的机制  

Mechanism of Helicobacter Pylori Inducing Gastric Cancer through Gastric Cancer Stem Cells

作　　者：杨静 王军[2,3] 路红[2,3] 任茜[2,3] 王玉平[2,3] 关泉林[4] 周永宁[2,3] YANG Jing;WANG Jun;LU Hong;REN Qian;WANG Yuping;GUAN Quanlin;ZHOU Yongning(The First School of Clinical Medicine of Lanzhou University,Lanzhou 730000,China;Key Laboratory of Gastrointestinal Diseases in Gansu Province,Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,the First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Oncology Surgery,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学甘肃省胃肠病重点实验室,兰州730000 [3]兰州大学第一医院消化科,兰州730000 [4]兰州大学第一医院肿瘤外科,兰州730000

出　　处：《医学综述》2021年第1期84-89,共6页Medical Recapitulate

基　　金：国家自然科学基金(81570783,71964021);国家重点研发计划(2017YFC0908302,2016YFC1302201);甘肃省自然科学基金(18JR3RA351,18JR3RA352,18JR3RA366)。

摘　　要：胃癌干细胞(GCSCs)具有无限自我更新、多重分化、启动肿瘤生长和转移的潜能,CD44、CD133、CD24、Musashi-1等标志物的发现揭示了肿瘤细胞学行为和疾病进展相关的新信息。幽门螺杆菌(Hp)感染与胃癌有共同的流行病学特点,胃癌高发区人群Hp感染率较高,且Hp抗体阳性人群发生胃癌的危险性高于阴性人群。虽然Hp感染与胃癌的关系已得到证实,但其在肿瘤早期发生和进展中的机制仍不清楚。随着肿瘤干细胞生物学领域研究的不断扩大,研究Hp通过GCSCs诱导胃癌发生的机制,可能成为Hp诱导胃癌发生机制的重要步骤,为胃癌的诊断和治疗提供新方法。Gastric cancer stem cells(GCSCs)have the potential for unlimited self-renewal,multiple differentiation,initiating tumor growth and metastasis,while the discovery of markers such as CD44,CD133,CD24,and Musashi-1 has revealed new information related to tumor cytological behavior and disease progression.Helicobacter pylori(Hp)infection and gastric cancer share common epidemiological features,that the prevalence of Hp infection is higher in the population with a high incidence of gastric cancer,while a higher risk of gastric cancer is observed in Hp antibody-positive populations than in negative populations.Although the relationship between Hp infection and gastric cancer has been established,the mechanism of its early onset and progression in tumorigenesis remains unclear.With the expanding research in the field of tumor stem cell biology,studying the mechanism of Hp-induced gastric carcinogenesis through GCSCs may become an important step in the research on the mechanism of Hp-induced gastric carcinogenesis and provide a new method for the diagnosis and treatment of gastric cancer.

关 键 词：胃癌 幽门螺杆菌 胃癌干细胞 上皮-间充质转化 

分 类 号：R735.2[医药卫生—肿瘤]