CTCs监测肿瘤转移机制及在结直肠癌诊疗中的应用  

Mechanism of CTCs Monitoring Tumor Metastasis and Its Application in Diagnosis and Treatment of Colorectal Cancer

作　　者：程煌荣 郑勇斌[1] CHENG Huangrong;ZHENG Yongbin(Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胃肠外科,武汉430060

出　　处：《医学综述》2021年第1期90-94,共5页Medical Recapitulate

基　　金：国家自然科学基金(81372553)。

摘　　要：肿瘤发生远处转移是导致肿瘤患者死亡的主要原因,外周血中循环肿瘤细胞(CTCs)的存在可能是肿瘤远处转移的基础。CTCs是实体肿瘤远处播散的种子,通过对外周血CTCs水平的动态监测,可以早期发现肿瘤的微转移。结直肠癌是一种全球高发病率和高致死率的恶性肿瘤,因此对结直肠癌的早期诊断以及患者的治疗效果评价和复发风险评估显得尤为重要。随着实验技术的不断发展,CTCs作为结直肠癌临床诊疗及患者预后评估等方面的肿瘤组织替代物的重要应用价值逐渐显现。Tumor metastasis is the main cause of death of tumor patients.The presence of circulating tumor cells(CTCs)in peripheral blood may be the basis of distant tumor metastasis.CTCs are seeds that spread far away from solid tumors.By dynamically monitoring the level of CTCs in the peripheral blood,we can detect micrometastasis of tumors in an earlier stage.For colorectal cancer,which is a kind of malignant tumor with high incidence and mortality worldwide,the early diagnosis,the evaluation of the treatment effect and the risk of recurrence are particularly important.With the continuous development of the experimental technology,more and more studies have shown that CTCs,as a substitute for tumor tissue,have important applicative value in the clinical diagnosis,treatment and prognosis assessment of colorectal cancer.

关 键 词：结直肠癌 循环肿瘤细胞 肿瘤转移 

分 类 号：R735.3[医药卫生—肿瘤]