PEG-rhG-CSF对80例小细胞肺癌同步放化疗预防中性粒细胞减少的临床观察  

Clinical observation of PEG-rhG-CSF in preventing neutropenia in 80 patients with small cell lung cancer treated with concurrent chemoradiotherapy

作　　者：张喜琴 祝守慧 刘宁[2] 王玉 陈家帧 胡旭东[2] ZHANG Xiqin;ZHU Shouhui;LIU Ning;WANG Yu;CHEN Jiazhen;HU Xudong(Shandong First Medical University,Jinan 250000,Shandong,China;Department of Radiation Oncology,Affiliated Cancer Hospital of Shandong First Medical University,Jinan 250117,Shandong,China)

机构地区：[1]山东第一医科大学,山东济南250000 [2]山东第一医科大学附属肿瘤医院(山东省肿瘤医院)放射肿瘤科,山东济南250117

出　　处：《山东大学学报（医学版）》2020年第12期43-46,59,共5页Journal of Shandong University:Health Sciences

基　　金：中国临床肿瘤学会希思科-齐鲁肿瘤研究基金(Y-Q201801-054)。

摘　　要：目的探讨聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)在小细胞肺癌患者同步放化疗中中性粒细胞减少的预防效果。方法回顾性分析在山东省肿瘤医院行同步放化疗、且预防使用PEG-rhG-CSF的小细胞肺癌病例80例(观察组),根据年龄、性别等因素1∶1匹配了未使用PEG-rhG-CSF的对照组80例。观察比较两组的中性粒细胞减少情况。结果同步放化疗后,观察组和对照组的白细胞均减少,但前者(3.15±0.76)×10^9个/L高于后者(1.82±0.77)×10^9个/L,差异有统计学意义(Z=-8.467,P<0.001);观察组与对照组同步放化疗前,两组中性粒细胞绝对值差异无统计学意义(Z=-1.543,P=0.123),同步放化疗后观察组中性粒细胞减至(1.89±0.52)×10^9个/L,对照组减至(0.77±0.44)×10^9个/L,观察组绝对值减少幅度低于对照组,差异有统计学意义(Z=-10.034,P<0.001)。结论使用PEG-rhG-CSF对预防白细胞、中性粒细胞绝对值的降低有作用,可改善中性粒细胞减少,但尚待大样本验证。Objective To investigate the preventive effect of pegylated recombinant human granulocyte colony stimulating factor(PEG-rhG-CSF)on neutropenia in patients with small cell lung cancer(SCLC).Methods A retrospective analysis of 80 SCLC cases(observation group)who received concurrent chemoradiotherapy and prophylactic use of PEG-rhG-CSF in Shandong Cancer Hospital was conducted,and 80 controls without useing PEG-rhG-CSF were matched according to age,gender and other factors.The neutropenia was observed and compared between the two groups.Results After concurrent chemoradiotherapy,the leukocytes count decreased in both groups,which was(3.15±0.76)×10^9 cells/L in the observation group and(1.82±0.77)×10^9 cells/L in the control group(Z=-8.467,P<0.001).Before chemoradiotherapy,there was no significant difference in the absolute value of neutrophils between the two groups(Z=-1.543,P=0.123).After chemoradiotherapy,the number of neutrophils decreased to(1.89±0.52)×10^9 cells/L in the observation group and(0.77±0.44)×10^9 cells/L in the control group.The decrease in the observation group was lower than that in the control group(Z=-10.034,P<0.001).Conclusion PEG-rhG-CSF can prevent the decrease of leukocytes and neutrophils,but experiments with larger samples are still needed for proof.

关 键 词：聚乙二醇化重组人粒细胞集落刺激因子 小细胞肺癌 同步放化疗 骨髓抑制 预防效果 

分 类 号：R734.2[医药卫生—肿瘤]