疱疹病毒ICP22蛋白研究进展  

Research Progress of Herpes Virus ICP22 Protein

作　　者：李阳光 吴英 汪铭书[1,2,3] 程安春[1,2,3] LI Yangguang;WU Ying;WANG Mingshu;CHENG Anchun(Avian Disease Research Center,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China;Institute of Preventive Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China;Key Laboratory of Animal Disease and Human Health of Sichuan Province,Sichuan Agricultural University,Chengdu 611130,China)

机构地区：[1]四川农业大学动物医学院禽病防治研究中心,成都611130 [2]四川农业大学预防兽医研究所,成都611130 [3]四川农业大学动物疫病与人类健康四川省重点实验室,成都611130

出　　处：《畜牧兽医学报》2021年第1期9-18,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31602079);四川省教育厅重点项目(17ZA0309);现代农业产业技术体系专项(CARS-42-17);四川省科技厅项目(2017JY0014,2017HH0026);现代肉鹅产业链关键技术研究集成与示范(2018NZ0005);国家农业产业技术体系四川兽药创新团队专项(SCCXTD-2020-18)。

摘　　要：疱疹病毒(herpesvirus)是一类有囊膜结构的双链DNA病毒,典型结构由双链DNA基因组、衣壳(capsid)、皮层(tegument)和囊膜(envelope)组成。其家族庞大,迄今共发现了100多种,分为甲型(α)、乙型(β)、丙型(γ)疱疹病毒亚科。疱疹病毒宿主分布极其广泛,可感染两栖类、禽类、哺乳类、灵长类和人类,主要侵害皮肤、黏膜以及神经组织,严重影响着人类及其他动物的健康。感染细胞蛋白22(infected cell protein 22,ICP22)是US1或其同源基因编码的多功能蛋白,可与细胞和/或病毒成分相互作用而广泛发挥作用,如参与病毒潜伏感染期的建立、与RNA聚合酶Ⅱ(RNA polymeraseⅡ, RNA PolⅡ)相互作用影响病毒和宿主基因转录、影响病毒诱导分子伴侣富集域(virus-induced chaperone-enriched, VICE)区域的形成以及子代病毒粒子的核出芽、涉及细胞凋亡、自噬与抗病毒反应等。本文就疱疹病毒US1及同源基因编码蛋白ICP22的研究进展作一综述,以期为深入开展ICP22与病毒和宿主蛋白相互作用参与病毒复制和致病过程中的机制研究提供参考,对动物疱疹病毒、特别是以ICP22作为靶标的新药研究具有一定的参考价值。Herpesvirus is a type of double-stranded DNA virus with a capsule structure, which is mainly composed of a double-stranded DNA genome, capsid, tegument, and envelope. At present, more than 100 types of herpes virus have been found, which can be divided into α-, β-, γ-herpesvirus subfamilies. It infects a wide range of hosts, such as amphibians, birds, mammals, primates and humans, and so on. It mainly damages the skin, mucous membrane, and nerve tissue, and seriously affects the health of human and other animal. Infected cell protein 22 (ICP22) is a multifunctional protein encoded by US 1 or its homologous genes and can interact with cells and/or viral components to exert a wide range of functions. It can be involved in the establishment of latent infection period of viruses, the interaction with RNA polymerase Ⅱ (RNA Pol Ⅱ) to affect the transcription of viral and host genes, the formation of viral-induced chaperone-enriched (VICE) regions, and the nuclear budding of progeny viral particles, involving apoptosis, autophagy, and antiviral response, etc. This article reviews the research progress of herpes virus US1 and its homologous genes, and the encoding protein ICP22. We hope it will provide new ideas and directions for further research on the interaction mechanism of ICP22 with other virus and host proteins involved in physiological and pathological processes, and we also hope it will provide a certain reference value for the research of animal herpes virus, especially the new drugs targeting ICP22.

关 键 词：疱疹病毒 ICP22 转录调控 核出芽 凋亡 自噬 

分 类 号：S852.659.1[农业科学—基础兽医学]