The National Natural Science Foundation of China (30670094, 30700028);the Ph.D. Programs Foundation of Ministry of Education of China (2006-0023008)
Nuclear proteins often form punctiform structures, but the precise mechanism for this process is unknown. As a preliminary study, we investigated the aggregation of an HSV-1 immediate-early protein, infected-cell prot...
The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science(20071010141);National Natural Science Foundation of China (30870120);Open Research Fund Program of the State Key Laboratory of Virology of China(2007003,2009 007);Hubei Province Natural Science Foundation of Innovation Groups Project(2008CDA013)
As one of the immediate-early(IE)proteins of herpes simplex virus type 1(HSV-1),ICP22 is a multifunctional viral regulator that localizes in the nucleus of infected cells.It is required in experimental animal systems ...
Supported by the National Natural Science Foundation (Grant No. 30570081, 30670094);Doctoral Fund of Ministry of Education of China (Grant No. 20060023053)
Herpes Simplex Virus 1 (HSV1) is capable of inducing two forms of infection in individuals, and the establishment of which type of infection occurs is linked to the transcriptional activation of viral α genes. One of...
The three immediate-early proteins of HSV-1, ICP0, ICP22, and ICP27, have specific and pivotal functions in transcriptional activation and inhibition, multiple regulatory and control processes of viral genes. In this ...
The molecular mechanisms mediating herpes simplex virus type 1 (HSV- 1) gene silencing during latent infection are not clear. Five copies of early growth response gene 1 (Egr-1) binding elements were identified in...