磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用  

Application of Phosphoramidate Prodrugs Strategies and ProTide Technology in Anti-Virus Drug Discovery

作　　者：孙孝斌 苗志伟[1] Xiaobin Sun;Zhiwei Miao(State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,P.R.China.)

机构地区：[1]南开大学化学学院,元素有机化学国家重点实验室,天津300071

出　　处：《大学化学》2020年第12期35-43,共9页University Chemistry

基　　金：天津市科技支撑重点项目(19YFZCSN00240);南开大学中央高校基本科研业务费专项资金(63201023)。

摘　　要：抗病毒药物是人类战胜病毒的有力武器,2019年底爆发的新型冠状病毒肺炎(COVID-19)疫情给人类带来巨大危害,同时也使人们意识到研发抗病毒药物的重要性。本文综述了磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用,介绍了核苷-磷酰胺酯前药的合成策略,概述了核苷-磷酰胺酯在不同抗病毒药物中的应用,为新型抗病毒药物研发提供借鉴和参考。Antiviral drug is a powerful weapon for humans to defeat the virus.The spread of 2019 novel coronavirus pneumonia(COVID-19)outbreak has a serious impact on the world.At the same time,it also makes people aware of the importance of antiviral drug development.This article reviews the application of the phosphoramidate prodrug strategy and the application of ProTide technology in the development of antiviral drugs.The synthesis methods of nucleoside-phosphoramidate prodrugs are introduced.The application of nucleoside-phosphoramidate in different antiviral drugs is also summarized.This review can provide a reference for the development of new antiviral drugs in the future.

关 键 词：抗病毒药物研发 核苷-磷酰胺酯前药 ProTide技术 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]