丹参川芎嗪联合尤瑞克林治疗对老年急性缺血性脑卒中患者脑血流动力学及TLR4/NF-κB信号通路的影响  

Effects of salvia ligustrazine combined with urinary kallindinogenase on cerebral hemodynamics and TLR4/NF-κB signal pathway level in elderly patients with acute ischemic stroke

作　　者：杨云鹏[1] 郭刚[1] 张璐璐[1] YANG Yun-peng;GUO Gang;ZHANG Lu-lu(Department of Neurology,Xi'an Fourth Hospital,Xi'an 710004,Shaanxi,CHINA)

机构地区：[1]西安市第四医院神经内科,陕西西安710004

出　　处：《海南医学》2021年第1期26-30,共5页Hainan Medical Journal

摘　　要：目的探讨丹参川芎嗪联合尤瑞克林治疗对老年急性缺血性脑卒中(ACI)患者脑血流动力学及Toll样受体4(TLR4)/核因子-κB(NF-κB)信号通路的影响。方法选取2017年10月至2019年12月西安市第四医院神经内科收治的126例老年ACI患者为研究对象,按随机数表法分为观察组、对照A组和对照B组,每组42例。在常规治疗基础上,对照A组给予丹参川芎嗪治疗,对照B组给予尤瑞克林治疗,观察组患者则给予丹参川芎嗪联合尤瑞克林治疗,均治疗两周。比较三组患者的临床疗效以及治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力评分量表(ADL)、血清氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]、细胞凋亡有关因子[B淋巴细胞瘤-2(Bcl-2)、Livin、可溶性细胞凋亡因子(sFas)、可溶性细胞凋亡因子配体(sFasL)]、脑血流动力学指标[平均血流速度(Vmean)、平均血流量(Qmean)、脑血管特征性阻抗(ZCV)、动态阻抗(DR)]和TLR4/NF-κB信号通路水平。结果观察组患者的治疗总有效率为92.86%,明显高于对照A组的74.43%和对照B组的73.81%,差异有统计学意义(P<0.05);观察组患者治疗后的NIHSS评分明显低于对照A组、对照B组,ADL评分明显高于对照A组、对照B组,差异均有统计学意义(P<0.05);观察组患者治疗后的血清SOD水平明显高于对照A组、对照B组,血清MDA水平明显低于对照A组、对照B组,差异均有统计学意义(P<0.05);观察组患者治疗后的血清Bcl-2、Livin水平明显高于对照A组、对照B组,血清sFas、sFasL水平明显低于对照A组、对照B组,差异均有统计学意义(P<0.05);观察组患者治疗后的Vmean、Qmean水平明显高于对照A组、对照B组,ZCV、DR水平明显低于对照A组、对照B组,差异均有统计学意义(P<0.05);观察组患者治疗后的TLR4、NF-κB水平明显低于对照A组、对照B组,差异均有统计学意义(P<0.05);除DR外,对照A组和对照B组患者治�Objective To investigate the effect of salvia ligustrazine combined with urinary kallindinogenase on cerebral hemodynamics and Toll-like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)signaling pathway levels in elderly patients with acute ischemic stroke(ACI).Methods From October 2017 to December 2019,126 elderly ACI patients admitted to the Department of Neurology,Xi'an Fourth Hospital were selected as the research subbjects.They were divided into observation group,control group A,and control group B by random number table,with 42 patients in each group.On the basis of conventional treatment,the control group A was treated with salvia ligustrazine,the control group B was treated with urinary kallindinogenase,and the observation group was treated with salvia ligustrazine combined with urinary kallindinogenase,for 2 weeks.The clinical efficacy,the National Institutes of Health Stroke Scale(NIHSS)score,and the ability of daily living scale(ADL),serum oxidative stress indicators(superoxide dismutase[SOD],malondialdehyde[MDA]),apoptosis-related factors(B lymphoma-2[Bcl-2],Livin,soluble apoptosis factor[sFas],soluble apoptosis factor ligand[sFasL]),cerebral hemodynamic indicators(average blood flow velocity[Vmean],average blood flow[Qmean],cerebrovascular characteristic impedance[ZCV],dynamic impedance[DR]),and TLR4/NF-κB signal pathway levels before and after treatment of the three groups was compared.Results The total effective rate of treatment in the observation group was 92.86%,which was significantly higher than 74.43%in the control group A and 73.81%in the control group B(P<0.05).The NIHSS score of the observation group after treatment was significantly lower than that of the control group A and control group B,and the ADL score was significantly higher than that of the control group A and control group B(P<0.05).The serum SOD level of patients in the observation group after treatment was significantly higher than that of the control group A and control group B,and the serum MDA level was significantly lower

关 键 词：老年 急性缺血性脑卒中 丹参川芎嗪 尤瑞克林 脑血流动力学 Toll样受体4 核因子-ΚB 

分 类 号：R743.3[医药卫生—神经病学与精神病学]