血清TNF-α、IFN-γ表达对后腹腔镜肾癌部分切除术患者预后的预测价值  

Value of serum TNF-αand IFN-γexpression in predicting the prognosis of patients undergoing retroperitoneal partial renal resection

作　　者：王晨青 索杰[1] 罗晓辉[1] 王波 黄晓东[1] 王进[1] WANG Chen-qing;SUO Jie;LUO Xiao-hui;WANG Bo;HUANG Xiao-dong;WANG Jin(Department of Urology,Baoji Central Hospital,Baoji 721000,Shaanxi,CHINA)

机构地区：[1]宝鸡市中心医院泌尿外科,陕西宝鸡721000

出　　处：《海南医学》2021年第1期49-52,共4页Hainan Medical Journal

摘　　要：目的探讨血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)表达对后腹腔镜肾癌部分切除术患者预后的预测价值。方法回顾性分析2016年3月至2017年3月间于宝鸡市中心医院行后腹腔镜肾癌部分切除术的79例早、中期肾癌患者的临床资料,根据术后3年随访结果分为预后良好组(A组,58例)、预后较差组(B组,21例),并选取71例同期体检正常志愿者为对照组。检测并比较三组受检者的血清TNF-α、IFN-γ表达水平,采用ROC曲线分析血清TNF-α、IFN-γ表达对患者预后的预测价值。结果三组受检者的性别、年龄、体质量指数(BMI)比较差异均无统计学意义(P>0.05);A组与B组患者的病程、肿瘤类型、临床分期、病理分级比较差异均无统计学意义(P>0.05);A组、B组和对照组受检者的血肌酐(Scr)[(102.69±13.28)μmol/L vs(118.29±22.90)μmol/L vs(71.61±10.46)μmol/L]、尿素氮(BUN)[(9.67±2.26)mmol/L vs(11.26±2.89)mmol/L vs(7.35±1.44)mmol/L]比较,A组和B组明显高于对照组,B组明显高于A组,差异均有统计学意义(P<0.05);A组、B组和对照组受检者的血清TNF-α[(3.68±1.18)pg/mL vs(2.09±0.61)pg/mL vs(5.06±1.42)pg/mL]、IFN-γ[(6.88±1.68)pg/mL vs(5.26±1.06)pg/mL vs(8.04±2.25)pg/mL]比较,A组和B组明显低于对照组,B组明显低于A组,差异具有统计学意义(P<0.05);ROC曲线分析结果显示,TNF-α、IFN-γ对后腹腔镜肾癌部分切除术预后具有一定预测价值(AUC=0.814、0.843,P<0.01),且两项联合预测价值较高(AUC=0.901,P<0.01)。结论后腹腔镜肾癌部分切除术患者血清TNF-α、IFN-γ水平表达低者,预后不良发生率较高。Objective To explore the predictive value of serum tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)expression in the prognosis of patients undergoing retroperitoneal laparoscopic partial renal resection.Methods The clinical data of 79 early and mid-stage renal cancer patients who underwent retroperitoneal laparoscopic partial renal resection in Baoji Central Hospital from March 2016 to March 2017 were retrospectively analyzed.The prognosis was divided into the good pronosis group(group A,58 cases)and poor prognosis group(group B,21 cases)according to 3-year follow-up results,and 71 normal volunteers during the same period of physical examination were selected as the control group.The serum TNF-αand IFN-γexpression levels of the three groups of subjects were detected and compared,and ROC curve was used to analyze the predictive value of serum TNF-αand IFN-γexpression on the prognosis of patients.Results There were no statistically significant differences in gender,age,and body mass index(BMI)of the three groups of subjects(all P>0.05);there was no difference in the course of disease,tumor type,clinical stage,and pathological grade between group A and group B(all P>0.05);serum creatinine(Scr)and urea nitrogen(BUN)in group A and group B were(102.69±13.28)μmol/L and(118.29±22.90)μmol/L,(9.67±2.26)mmol/L and(11.26±2.89)mmol/L,which were significantly higher than(71.61±10.46)μmol/L and(7.35±1.44)mmol/L in the control group,and those of the group B was also significantly higher than group A(all P<0.05);the serum TNF-αand IFN-γin group A and group B were(3.68±1.18)pg/mL and(2.09±0.61)pg/mL,(6.88±1.68)pg/mL and(5.26±1.06)pg/mL,which were significantly lower corresponding(5.06±1.42)pg/mL and(8.04±2.25)pg/mL in the control group,and those in group B was also significantly lower than group A(all P<0.05);ROC curve analysis results showed that TNF-αand IFN-γwere effective in retroperitoneal laparoscopic partial resection of renal cancer.The prognosis had a certain predictive value(AUC=0.814,0.84

关 键 词：血清肿瘤坏死因子-Α 干扰素-Γ 后腹腔镜肾癌部分切除术 预后 复发转移 

分 类 号：R737.11[医药卫生—肿瘤]