电压门控钙通道编码基因在孤独症谱系障碍中的研究进展  

Research progresson voltage-gated calcium channel-encoding genes in autism spectrum disorders

作　　者：焦翠 柳涛[1] JIAO Cui;LIU Tao(Department of Pediatrics,the First Affiliated Hospital of Nanchang University,Nanchang,Jinagxi 330006,China)

机构地区：[1]南昌大学第一附属医院儿科,江西南昌330006

出　　处：《中国儿童保健杂志》2021年第1期47-51,共5页Chinese Journal of Child Health Care

基　　金：国家自然科学基金(31660289);江西省杰出青年人才资助计划(20171BCB23091);南昌大学研究生创新专项资金项目(CX2018166)。

摘　　要：孤独症谱系障碍(ASD)是一类以社交障碍和兴趣狭窄为共同症状的广泛性神经发育障碍,发病机制主要与遗传因素有关,研究ASD易感基因是现今国内外医学领域的热点。电压门控钙离子通道(VGCC)对调控神经元动作电位的产生和神经递质的释放等至关重要。目前VGCC的10种亚型均被发现与ASD相关。本文主要综述了编码VGCC的10种基因与ASD研究工作的进展。Autism spectrum disorder(ASD) is a generalized neurodevelopmental disorder with social disorders and narrow interest as common symptoms.Genetic contributions are its main pathogenesis.Research on ASD susceptibility genes is a hot topic in the medical field at home and abroad.Voltage-gated calcium channels(VGCC) are essential for the regulation of neuronal action potential and neurotransmitter release.Currently, all 10 subtypes of the VGCC encoding genes have been found to be associated with ASD.So this review aims to summarize the research progress of the 10 genes encoding VGCC and ASD.

关 键 词：电压门控钙通道 孤独症谱系障碍 编码基因 

分 类 号：R749.94[医药卫生—神经病学与精神病学]