胃癌、肠癌患者凝血参数的应用价值  

Application Value and Correlation Analysis of Coagulation Parameters in Patients with Gastric Cancer and Colorectal Cancer

作　　者：陈艳[1] 郭俊英[1] 高嫣妮[1] 陈德东[1] 陈燕[1] CHEN Yan;GUO Junying;GAO Yanni;CHEN Dedong;CHEN Yan(Fujian Medical University Cancer Hospital,Fuzhou 350001,China;不详)

机构地区：[1]福建医科大学附属肿瘤医院,福建福州350001

出　　处：《中国医学创新》2020年第36期1-5,共5页Medical Innovation of China

基　　金：国家自然科学基金项目(81802631);福建省科技计划项目(2018Y2003);福建省科技创新联合基金项目(2017Y9073)。

摘　　要：目的:探讨D-二聚体(D-dimer,D-D)、纤维蛋白降解产物(fibrinogen degradation product,FDP)及纤维蛋白单体(fibrin monomer,FM)检测在评估胃癌、肠癌凝血状态中的应用价值.方法:采用免疫比浊法对2016年5月-2019年4月在福建省肿瘤医院住院患者胃癌104例(胃癌组)、肠癌105例(肠癌组)及健康体检者40例(健康对照组)进行D-D、FDP及FM检测.结果:胃癌组、肠癌组D-D、FDP、FM含量均明显高于健康对照组(P<0.05);Ⅲ~Ⅳ期胃癌、肠癌患者D-D、FDP及FM含量均明显高于Ⅰ~Ⅱ期胃癌、肠癌患者.胃癌、肠癌患者化疗后D-D、FM含量均增高(P<0.05).胃癌、肠癌患者术后D-D、FDP及FM含量均增高(P<0.05).根据各项目指标间的相关性分析,考虑检验过程可能产生假性结果.结论:D-D、FDP、FM可为胃癌、肠癌等恶性肿瘤患者的高凝及出血状态提供临床预警,但应考虑检验过程产生的假性结果及影响因素,联合动态检测能更准确为临床提供参考依据.Objective:To explore the application value of D-dimer(D-D),fibrinogen degradation product(FDP)and fibrin monomer(FM)in the evaluation of gastric cancer and colorectal cancer coagulation status.Method:The levels of D-D,FDP and FM of 104 cases of gastric cancer(gastric cancer group),105 cases of intestinal cancer(colorectal cancer group)and 40 cases of healthy physical examination(healthy control group)in Fujian Cancer Hospital from May 2016 to April 2019 were detected by immunoturbidimetry.Result:The contents of D-D,FDP and FM in gastric cancer group and colorectal cancer group were significantly higher than those in healthy control group(P<0.05).The levels of D-D,FDP and FM in patients with stageⅢ-Ⅳgastric cancer and colorectal cancer were significantly higher than those in patients with stageⅠ-Ⅱgastric cancer and colorectal cancer(P<0.05).The levels of D-D,FDP and FM were increased in patients with gastric cancer and colorectal cancer after operation(P<0.05).According to the correlation analysis of each item index,it was considered that the test process may produce false results.Conclusion:D-D,FDP and FM can provide clinical warning for the hyper coagulability and bleeding status of patients with gastric cancer,colorectal cancer and other malignant tumors.However,the false results and influencing factors generated during the test should be considered,and the combined dynamic detection can provide more accurate clinical reference.

关 键 词：D-二聚体 纤维蛋白原降解产物 纤维蛋白单体 胃癌 肠癌 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]