妊娠哺乳期乳腺癌8例临床分析  

Clinical analysis of 8 cases of pregnancy-associated breast cancer

作　　者：贾国从 刘莉 刘艺萌 何婧 JIA Guocong;LIU Li;LIU Yimeng;HE Jing(Department of the Second Ward of Breast Surgery,Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院乳腺外科二病区,河南郑州450052

出　　处：《我和宝贝》2021年第1期53-55,共3页Baby and Me

摘　　要：目的探讨妊娠哺乳期乳腺癌患者的临床特点、治疗方法和妊娠结局。方法回顾性分析2016年1月~2018年1月我院乳腺外科收治的8例妊娠哺乳期乳腺癌患者的临床资料,总结妊娠哺乳期乳腺癌的临床特点及妊娠结局。结果8例妊娠哺乳期乳腺癌患者中妊娠期乳腺癌5例,哺乳期乳腺癌3例;临床分期0期1例,Ⅱ期4例,Ⅲ期3例。5例妊娠期患者中期引产2例,早产剖宫产1例,足月顺产1例,足月剖宫产1例;8例妊娠哺乳期乳腺癌患者随访8~33个月,平均(20.5±7.5)个月,4例患者乳腺癌根治术后出现全身多发转移,其余4例患者未见复发和转移;共分娩新生儿3例,随访6~45个月未见异常。结论妊娠哺乳期乳腺癌预后较差,易复发,除胎儿因素外,其治疗原则与非妊娠期乳腺癌相同;应提高妊娠哺乳期乳腺癌早期诊断率,确诊后积极采取根治性手术,不建议常规治疗性终止妊娠,妊娠期可行手术或选择性化学治疗,以获得最佳妊娠结局。Objective To explore the clinical characteristics,treatment and pregnancy outcome of patients with pregnancy-associated breast cancer.Methods The clinical data of 8 patients with pregnancy-associated breast cancer in our hospital from January 2016 to January 2018 were retrospectively analyzed,and the clinical characteristics and pregnancy outcomes of breast cancer during pregnancy and lactation were summarized.Results There were 5 cases of breast cancer during pregnancy and 3 cases of breast cancer in laction among 8 cases of pregnancy-associated breast cancer,1 case of stage 0,4 cases of stageⅡ,and 3 cases of stageⅢ.There were 2 cases of induced labor in the second trimester of pregnancy,1 case of premature cesarean section,1 case of full-term natural labor and 1 case of full-term cesarean section in 5 cases of breast cancer during pregnancy.A total of 8 cases of breast cancer during pregnancy and lactation were followed up for 8 to 33 months,with an average of(20.5±7.5)months,four patients had multiple metastasis after radical mastectomy,and the other four patients had no recurrence or metastasis.A total of 3 neonates were delivered,and no abnormalities were observed after 6 to 45 months follow-up.Conclusion The prognosis of breast cancer during pregnancy and lactation is poor,and it is easy to relapse,the early diagnosis rate of breast cancer during pregnancy and lactation should be improved.Radical operation should be taken after diagnosis,and no conventional treatment termination of pregnancy is recommended,and operation or selective chemotherapy may be performed during pregnancy to obtain the best pregnancy outcome.

关 键 词：妊娠哺乳期乳腺癌 临床特点 妊娠结局 

分 类 号：R737.9[医药卫生—肿瘤] R714.25[医药卫生—临床医学]