基于静息态脑电微状态对成人注意缺陷多动障碍的判别  

Discrimination of adult with attention deficit/hyperactivity disorder based on EEG microstate

作　　者：陈彦博 王长明 李卉[1] 赵琦华[1] 罗翔升 吴占良[1] 曹庆久[1] 孙黎[1] 王玉凤[1] CHEN Yanbo;WANG Changming;LI Hui;ZHAO Qihua;LUO Xiangsheng;WU Zhanliang;CAO Qingjiu;SUN Li;WANG Yufeng(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,China;Beijing Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083 [2]首都医科大学附属北京宣武医院,北京100053

出　　处：《中国心理卫生杂志》2021年第2期159-164,共6页Chinese Mental Health Journal

基　　金：国家自然科学基金(81771479、81971284);北京市科技计划项目(Z171100001017089);首都卫生发展科研专项项目(2020-1-4111)。

摘　　要：目的:探究注意缺陷多动障碍(ADHD)患者的静息态脑电微状态特征及其对成人ADHD的判别能力。方法:收集36例符合DSM-IV标准的成人ADHD患者和46例正常对照的静息态脑电数据,比较两组脑电微状态的时间覆盖率和优势切换方向。运用Fisher线性判别,探讨脑电微状态对ADHD的判别能力。结果:两组均呈现5种脑电微状态(A~E),ADHD组微状态C时间覆盖率低于对照组[(16.6±4.3)%vs.(23.6±6.6)%,P<0.001],微状态D时间覆盖率高于对照组[(21.6±4.1)%vs.(15.1±5.9)%,P<0.001]。微状态AB、AD、BC、BE、CD、DE之间的优势切换方向的组间差异有统计学意义(均P<0.05)。用时间覆盖率参数作判别准确率84.2%,优势切换方向参数作判别准确率91.5%。结论:用脑电微状态参数对ADHD相对于正常对照作判别有较高的正确率,值得进一步探讨临床应用前景。Objective:To explore EEG microstate in adult with ADHD and its ability in discrimination.Methods:The EEG data was collected from 36 adult ADHD patients in accordance with DSM-IV and 46 age,sex and IQ matched health controls.Microstate coverage and transition were compared,respectively.Discrimination accuracy through fisher linear discriminant was analyzed.Results:Five microstates were clustered in both the ADHD and control group(A-E).The coverage of microstate C significantly decreased[(16.6±4.3)%vs.(23.6±6.6)%,P<0.001]whereas that of microstate D significantly increased[(21.6±4.1)%vs.(15.1±5.9)%,P<0.001]in ADHD group.Microstate transitions of AB,AD,BC,BE,CD and DE are significantly different between the two groups(P<0.05).The accuracy based on coverage and transition were 84.2%and 91.5%,respectively.Conclusion:There is a high accuracy to use EEG microstate distinguish ADHD,which is worthy of further discussion on the prospect of clinical application.

关 键 词：注意缺陷多动障碍 脑电微状态 判别分析 

分 类 号：R749.044[医药卫生—神经病学与精神病学]