神经影像在卒中后脑可塑性机制中的应用进展  

Advance in Application of Neuroimaging in Plasticity Mechanism after Stroke(review)

作　　者：张豪杰 李芳[1,2] 李晁金子[1,2] 米海霞[1,2] 刘旭 白晨 李冰洁[1,2] 杜晓霞[1,2] 张通[1,2] ZHANG Hao-jie;LI Fang;LI Chao-jin-zi;MI Hai-xia;LIU Xu;BAI Chen;LI Bing-jie;DU Xiao-xia;ZHANG Tong(Capital Medical University School of Rehabilitation Medicine,Beijing 100068,China;Department of Neurology,Beijing Bo'ai Hospital,China Rehabilitation Research Centre,Beijing 100068,China)

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院神经康复中心,北京市100068

出　　处：《中国康复理论与实践》2021年第1期48-53,共6页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中国康复研究中心项目(No.2018ZX-10);中央级公益性科研院所基本科研业务费专项基金项目(No.2018CZ-2)。

摘　　要：神经影像技术是进行卒中后脑可塑性机制研究的重要手段。弥散张量成像可用于描述白质纤维束结构,评估受损程度,但不能反映不同脑区之间的功能联系;任务态功能磁共振成像(fMRI)可检测特定任务引起对应的脑区激活情况,但试验设计复杂,对受试者要求高;静息态fMRI可进行复杂脑网络分析,反映不同脑区功能联系,但数据分析方法复杂;功能近红外光谱技术(fNIRS)用非侵入性方法反映脑区功能激活情况,相比fMRI,fNIRS有更好的时间分辨率,但空间分辨率稍差。多种检测手段结合可能是将来研究的重要方向。Neuroimaging technique is a kind of significant means to explore the mechanism of cerebral plasticity after stroke.Diffusion tensor imaging can be used to describe the structure of white matter fiber bundles and evaluate the degree of damage,but it cannot reflect the functional connections between different brain regions.Task-state functional magnetic resonance(fMRI)can detect the activation of corresponding brain regions caused by specific tasks,but the test design is complex and demanding for subjects.Resting-state fMRI can analyze complex brain networks and reflect functional connections in different brain regions,but the method of data analysis is complex.Functional near-infrared spectroscopy(fNIRS)is another non-invasive method to reflect the functional activation of brain regions,in which temporal resolution is better than fMRI,but the spatial resolution is slightly lower.The combination of multiple detection methods may be an important research direction in the future.

关 键 词：脑卒中 康复 可塑性 神经影像 磁共振成像 近红外光谱 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]