玻璃酸钠滴眼液联合障眼明片治疗中老年中重度干眼病疗效观察  

Observation of the curative effect of sodium hyaluronate eye drops combined with Zhangyanming tablets in the treatment of middle-aged and elderly patients with moderate to severe dry eye disease

作　　者：黄惠丽[1] 王伟 陈猛云 张怡[1] HUANG Huili;WANG Wei;CHEN Mengyun;ZHANG Yi(General Practice Department of Huamu Community Health Service Center,Pudong New District,Shanghai 201204,China;General Practice Department of traditional Chinese Medicine of Huamu Community Health Service Center of Pudong New District,Shanghai 201204,China)

机构地区：[1]上海市浦东新区花木社区卫生服务中心全科,上海201204 [2]上海市浦东新区花木社区卫生服务中心中医全科,上海201204

出　　处：《上海医药》2021年第2期32-34,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:观察玻璃酸钠滴眼液联合障眼明片治疗中老年中重度干眼病的临床疗效。方法:收集2017年1月—2019年1月上海市浦东新区花木社区卫生服务中心收治的中老年中重度干眼病患者260例,以就诊先后顺序随机分为对照组132例和治疗组128例。对照组给予人工泪液(玻璃酸钠滴眼液)外用滴眼,1~2滴/次,3次/d;治疗组在对照组基础上予以障眼明片,4片/次,3次/d。两组均连续用药4周为1个疗程,共3个疗程。比较眼部症状积分、角膜荧光染色(corneal fluorescence staining,FL)、泪液流量(Schirmer test,ST)、泪膜破裂时间(tear break-up time,BUT)及治疗有效率。结果:治疗组总有效率为87.50%,高于对照组的72.73%(P<0.05)。两组治疗后眼部症状积分、FL积分均较治疗前明显改善,且治疗组显著优于对照组(P<0.05);治疗后治疗组ST和BUT均较治疗前明显改善,且优于对照组(P<0.05)。结论:玻璃酸钠滴眼液联合障眼明片治疗中老年中重度干眼病疗效显著,值得在社区全科门诊中推广应用。Objective:To observe the clinical efficacy of sodium hyaluronate eye drops combined with Zhangyanming tablets in the treatment of middle-aged and elderly patients with moderate to severe dry eye disease.Methods:A total of 260 middle-aged and elderly patients with moderate to severe dry eye disease were collected from the General Outpatient Department of Huamu Community Health Service Center in Pudong New District of Shanghai from January 2017 to January 2019,and according to the order of visits,randomly divided into a control group with 132 cases and a treatment group with 128 cases.The control group was given artificial tears(sodium hyaluronate eye drops)for topical eye drops,1 to 2 drops/time,3 times/d;the treatment group was given Zhangyanming tablets on the basis of the control group,4 tablets/time,3 times/d.Both groups were treated continuously for 4 weeks as a course of treatment,totaling 3 courses.The scores of ocular symptoms,corneal fluorescence staining(FL),tear flow(Schirmer test,ST),tear break-up time(BUT),and treatment efficiency were compared.Results:The total effective rate in the treatment group was 87.50%,which was higher than that in the control group(72.73%)(P<0.05).After treatment,the scores of ocular symptoms and FL score of the two groups were significantly improved compared with before treatment,and the treatment group was significantly better than the control group(P<0.05);ST and BUT in the treatment group were significantly improved after treatment than before treatment,and were better than those in the control group(P<0.05).Conclusion:Sodium hyaluronate eye drops combined with Zhangyanming tablets in the treatment of middle-aged and elderly patients with moderate to severe dry eye disease has significant curative effect,which is worthy of promotion and application in the community general outpatient service.

关 键 词：干眼病 中重度 中老年 中西医结合治疗 疗效 

分 类 号：R777.31[医药卫生—眼科]