青年脑白质高信号与同型半胱氨酸的相关性研究  

Study on Correlation Between High White Matter Signal and Homocysteine in Young Brain

作　　者：牛慧艳[1] 刘燕[2] 张秀莉[1] 赵亮[1] 柴利卓 张占强[1] NIU Huiyan;LIU Yan;ZHANG Xiuli;ZHAO Liang;CHAI Lizhuo;ZHANG Zhanqiang(Hebei Province Zhuozhou Hospital,Zhuozhou,Hebei 072750,China;North China Petroleum Administration General Hospital,Renqiu,Hebei 062500,China)

机构地区：[1]河北省涿州市医院,河北涿州072750 [2]华北石油管理局总医院,河北任丘062500

出　　处：《大医生》2020年第19期3-5,共3页Doctor

基　　金：河北省保定市重点支撑课题(编号:17ZF292)。

摘　　要：目的探讨青年脑白质高信号型脑小血管病的发生与同型半胱氨酸的相关性。方法选取河北省涿州市医院2018年10月至2019年10月进行健康体检的人群315例作为研究对象,根据同型半胱氨酸(Hcy)的检测水平是否>15μmol/L分为Hcy升高组(160例)与Hcy正常组(155例)。两组受检者均行头颅磁共振平扫检查,收集并记录受检者的性别、血压、血糖、同型半胱氨酸(Hcy)水平及饮酒情况的指标。比较两组受检者的脑白质高信号型所占比例,并分析青年脑白质高信号与同型半胱氨酸的相关性。结果Hcy升高组受检者的白质高信号显著增多于Hcy正常组,组间比较差异有统计学意义(P<0.05);同时发现大量饮酒可导致青年Hcy水平升高。结论高Hcy水平是青年脑小血管病(CSVD)的危险因素,Hcy与高血压的相互作用共同导致早期脑白质高信号(WMH)改变,或者高Hcy水平可加重高血压病的脑损害。同时大量饮酒也可导致Hcy水平升高,是脑小血管病CSVD的危险因素。Objective To investigate the correlation between homocysteine and occurrence of cerebral small vascular disease with high signal of white matter in young people.Methods A total of 315 healthy people who underwent physical examination in Hebei Province Zhuozhou Hospital from October 2018 to October 2019 were selected as the subjects of the study.According to whether the homocysteine(Hcy)level was>15μmol/L or not,they were divided into the Hcy elevated group(n=160)and the normal Hcy group(n=155).The subjects in both groups underwent cranial magnetic resonance plain scan,and the gender,blood pressure,blood glucose,homocysteine(Hcy)level and alcohol consumption of the subjects were collected and recorded.The proportion of white matter hypersignal type in the two groups was compared,and the correlation between hypersignal and homocysteine was analyzed in young people.Results The high white matter signal of the Hcy increased group was significantly higher than that of the normal Hcy group,and the difference between the groups was statistically significant(P<0.05),and it is also found that heavy drinking can lead to increased Hcy levels in young people.Conclusion High Hcy level is a risk factor for CSVD in young people.The interaction between Hcy and hypertension leads to the change of early white matter hypersignal(WMH),or high Hcy level can aggravate the brain damage of hypertension.At the same time,heavy alcohol consumption can also lead to elevated Hcy level,which is a risk factor for cerebrovascular disease CSVD.

关 键 词：同型半胱氨酸 脑小血管病 脑白质 高信号 饮酒 相关性 

分 类 号：R74[医药卫生—神经病学与精神病学]