阻塞性睡眠呼吸暂停对非酒精性脂肪性肝病的影响  

Impact of obstructive sleep apnea on nonalcoholic fatty liver disease

作　　者：许青青 唐海英[2] 毛靖伟[1] XU Qingqing;TANG Haiying;MAO Jingwei(Department of Gastroenterology,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China;Respiratory and Sleep Clinic,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China)

机构地区：[1]大连医科大学附属第一医院消化内科,辽宁大连116011 [2]大连医科大学附属第一医院呼吸睡眠诊疗中心,辽宁大连116011

出　　处：《临床肝胆病杂志》2021年第1期192-195,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81500402)。

摘　　要：阻塞性睡眠呼吸暂停(OSA)引起机体长期处于慢性间歇性缺氧可导致多系统、多器官病变,严重者可发生心源性猝死。除合并呼吸、心脑血管、内分泌代谢等疾病外,OSA与消化系统疾病中的非酒精性脂肪性肝病(NAFLD)也有密切关联。简述了OSA和NAFLD的现状,叙述了OSA对NAFLD的影响,归纳了OSA影响NAFLD的机制,提出通过探索OSA影响NAFLD的可能机制,从OSA角度为NAFLD寻找新的潜在防治靶点,对延缓、甚至阻断NAFLD进展具有重要意义。Obstructive sleep apnea(OSA)may induce chronic intermittent hypoxia,which may lead to the disorders of multiple systems and organs and even sudden cardiac death in severe cases.Besides respiratory,cardiovascular,endocrine,and metabolic diseases,OSA is also closely associated with nonalcoholic fatty liver disease(NAFLD).This article briefly describes the current status of OSA and NAFLD,introduces the impact of OSA on NAFLD,and reviews the mechanisms of OSA in NAFLD.It is pointed out that clarifying the mechanisms of OSA in affecting NAFLD and discovering potential prevention and treatment targets for NAFLD from the aspect of OSA are of great significance in delaying and even blocking the progression of NAFLD.

关 键 词：睡眠呼吸暂停 阻塞性 非酒精性脂肪性肝病 低氧 

分 类 号：R575.5[医药卫生—消化系统] R56[医药卫生—内科学]