泮托拉唑钠治疗轻度急性胰腺炎的效果及对血清淀粉酶、前白蛋白和白蛋白水平的影响  

Curative Effect of Pantoprazole Sodium on Mild Acute Pancreatitis and Its Influences on Levels of Serum Amylase,Prealbumin and Albumin

作　　者：王珣[1] 韩一梅 曾会[1] 王成[1] 司毅[1] WANG Xun;HAN Yi-mei;ZENG Hui;WANG Cheng;SI Yi(Department of Gastroenterology,Hanzhong Central Hospital,Hanzhong,Shaanxi 723000,China)

机构地区：[1]汉中市中心医院消化内科,陕西汉中723000

出　　处：《解放军医药杂志》2021年第1期54-57,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：陕西省重点研发计划项目(2019SF-220)。

摘　　要：目的研究泮托拉唑钠对轻度急性胰腺炎的治疗效果及对血清淀粉酶、前白蛋白和白蛋白水平的影响。方法回顾性分析2017年1月—2019年1月收治的98例轻度急性胰腺炎的临床资料,依据治疗方法分为观察组和对照组,每组49例。对照组给予常规治疗,观察组在对照组基础上给予泮托拉唑钠治疗,治疗时间均为1周。比较2组总有效率及症状缓解时间,并分析2组治疗前后血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、淀粉酶、前白蛋白、白蛋白和白细胞计数变化,记录2组治疗期间不良反应发生情况。结果观察组治疗总有效率高于对照组,发热、腹痛及呕吐症状缓解时间短于对照组(P<0.05,P<0.01)。观察组TNF-α、IL-6、白细胞计数、血清淀粉酶和白蛋白水平低于对照组,前白蛋白水平高于对照组(P<0.05,P<0.01)。观察组治疗期间不良反应发生率低于对照组(P<0.01)。结论泮托拉唑钠能够抑制炎性因子释放和白细胞升高,降低患者血清淀粉酶和白蛋白水平,增高前白蛋白水平,对轻度急性胰腺炎疗效较好。Objective To study curative effect of Pantoprazole sodium on mild acute pancreatitis(MAP)and its influences on levels of serum amylase,prealbumin and albumin.Methods The clinical data of 98 patients with MAP admitted to Hanzhong Central Hospital from January 2017 to January 2019 were retrospectively analyzed.According to the treatment methods,they were divided into observation group and control group,with 49 patients in each group.The control group was given conventional treatment,while the observation group was given Pantoprazole sodium treatment on the basis of the control group,and the duration of treatment was 1 week.The total effective rate and symptom relief time of the two groups were compared,and the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),amylase,prealbumin,albumin and white blood cell(WBC)count were analyzed before and after treatment in the two groups,and the occurrence of adverse reactions during treatment in the two groups was recorded.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the remission time of symptoms such as fever,abdominal pain and vomiting was shorter than that in the control group(P<0.05,P<0.01).The TNF-α,IL-6 and WBC count as well as the serum amylase and albumin were lower,while the level of prealbumin was higher in the observation group,as compared with those in the control group(P<0.05,P<0.01).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.01).Conclusion Pantoprazole sodium can inhibit release of inflammatory factors and increase of white blood cells,reduce the level of serum amylase and albumin,increase prealbumin level in patients,which is effective in the treatment of MAP.

关 键 词：急性胰腺炎 泮托拉唑钠 血清淀粉酶 前白蛋白 肿瘤坏死因子-α 白介素-6 

分 类 号：R576[医药卫生—消化系统]