促炎/抑炎标志物与缺血性卒中  

Pro-inflammatory/anti-inflammatory markers and ischemic stroke

作　　者：戴琦 余艳华 陈雪梅 李军荣 Dai Qi;Yu Yanhua;Chen Xuemei;Li Junrong(Department of Neurology,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing 211100,China)

机构地区：[1]南京医科大学附属江宁医院神经内科,211100

出　　处：《国际脑血管病杂志》2020年第11期853-856,共4页International Journal of Cerebrovascular Diseases

基　　金：南京市卫生和青年人才培养项目(QRX17032);南京医科大学科技发展项目(NMUB2019240);南京医科大学康达学院科研发展项目(KD2019KYJJYB047);江宁区科技发展计划项目(2020SHSY0098)。

摘　　要：急性缺血性卒中以其高发病率、高致残率和高病死率给许多中国家庭带来沉重的负担。缺血性卒中发病后,血清中促炎和抑炎物质的平衡被打破。当血清促炎因子占优势而抑炎因子水平相对较低时,会放大炎症反应并导致病情恶化。新型炎性标志物的发现将为缺血性卒中的早期诊断和治疗提供新的思路。Acute ischemic stroke has brought a heavy burden to many Chinese families with its high incidence,high morbidity,and high mortality.After the onset of ischemic stroke,the balance of pro-inflammatory and anti-inflammatory substances in serum is broken.When serum pro-inflammatory factors are dominant and the level of anti-inflammatory factors is relatively low,it will amplify the inflammatory response and cause the disease to worsen.The discovery of new inflammatory markers will provide new ideas for the early diagnosis and treatment of ischemic stroke.

关 键 词：卒中 脑缺血 炎症 炎症介导素类 生物标志物 NF-κB I-κB蛋白质类 基质金属蛋白酶9 金属蛋白酶1组织抑制剂 白细胞介素-10 白细胞介素-1Β 1-烷基-2-乙酰甘油磷酸胆碱酯酶 脂联素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]