放化疗联合治疗对局限期小细胞肺癌患者血清Ki-67、VEGF及肿瘤标志物水平的影响  

Effects of chemotherapy combined with radiotherapy on serum Ki-67,VEGF and tumor markers in patients with locally limited small cell lung cancer

作　　者：吴敏 胡晓楚 项楠 岳顺[1] WU Min;HU Xiaochu;XIANG Nan;YUE Shun(Department of Oncology,Huaian First Hospital Affiliated to Nanjing Medical University,Huaian,Jiangsu 223000,Chin;Department of Radiotherapy,Huaian First Hospital Affiliated to Nanjing Medical University,Huaian,Jiangsu 223000,China;Department of Tumor Rdiotherapy,Changshu First People′s Hospital,Changshu,Jiangsu 215500,China)

机构地区：[1]南京医科大学附属淮安第一医院肿瘤内科,江苏淮安223000 [2]南京医科大学附属淮安第一医院放疗科,江苏淮安223000 [3]江苏省常熟市第一人民医院肿瘤放疗科,江苏常熟215500

出　　处：《国际检验医学杂志》2021年第1期103-107,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨放化疗联合治疗对局限期小细胞肺癌(LS-SCLC)患者血清Ki-67、血管内皮生长因子(VEGF)及肿瘤标志物水平的影响。方法选取2015年1月至2019年1月南京医科大学附属淮安第一医院和常熟市第一人民医院收治的86例LS-SCLC患者,按随机数字表法分为两组,每组43例,其中对照组给予单一化疗治疗,观察组实施放化疗联合治疗。比较两组近期疗效,分析两组治疗前后血清胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、细胞角蛋白19片段抗原(CYFRA21-1)、糖类抗原-125(CA-125)、Ki-67、血管内皮生长因子(VEGF)、循环内皮细胞(CEC)、内皮抑素(ES)水平。结果观察组总有效率为86.05%,高于对照组的67.44%,差异有统计学意义(P<0.05)。两组治疗后血清ProGRP、NSE、CEA、CYFRA21-1、CA-125、Ki-67、VEGF、CEC水平均低于治疗前,差异均有统计学意义(P<0.05),且观察组治疗后上述指标水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗后血清ES水平高于治疗前,差异有统计学意义(P<0.05),且观察组治疗后ES水平高于对照组,差异有统计学意义(P<0.05)。结论放化疗联合治疗LS-SCLC疗效确切,可能与血清肿瘤标志物、Ki-67、VEGF、CEC水平降低,血清ES水平升高有关。Objective To investigate the effects of chemotherapy combined with radiotherapy on serum Ki-67,vascular endothelial growth factor(VEGF)and tumor markers in patients with locally limited small cell lung cancer(LS-SCLC).Methods A total of 86 patients with LS-SCLC admitted to Huaian First Hospital Affiliated to Nanjing Medical University and Changshu First People's Hospital from January 2015 to January 2019 were selected and randomly divided into two groups,43 cases in each group.The control group was given single chemotherapy,while the observation group was treated with radiotherapy and chemotherapy.The short-term efficacy of the two groups was compared.The serum levels of gastrin releasing peptide precursor(ProGRP),neuron specific enolase(NSE),carcinoembryonic antigen(CEA),cytokeratin 19 fragment antigen(CYFRA21-1),carbohydrate antigen-125(CA-125),Ki-67,vascular endothelial growth factor(VEGF),circulating endothelial cells(CEC),endostatin(ES)were analyzed before and after treatment.Results The total effective rate of the observation group was 86.05%,which was higher than 67.44%of the control group,the differencs were statistically significant(P<0.05).The serum ProGRP,NSE,CEA,CYFRA21-1,CA-125,Ki-67,VEGF,CEC levels in the two groups after treatment were lower than those before treatment,the differences were statistically significan(P<0.05),and the levels of the above indicators in the observation group were lower than those in the control group after treatment,the differences were statistically significant(P<0.05).The serum ES levels of the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05),and which in the observation group was higher than that in the control group after treatment,the difference was statistically significant(P<0.05).Conclusion Chemoradiotherapy combined with chemotherapy is effective in the treatment of LS-SCLC,which may related to the decrease of serum tumor markers,Ki-67,VEGF,CEC and the increase of serum ES level.

关 键 词：放化疗联合治疗 局限期小细胞肺癌 肿瘤标志物 KI-67 血管内皮生长因子 

分 类 号：R734.2[医药卫生—肿瘤]