酶法检测肌酐水平降低的秘密:羟苯磺酸钙的干扰  

The secret of creatinine decrease by enzyme method:the interference of calcium dobesilate

作　　者：陈克娜(综述) 谌海兰(审校)[1] CHEN Kena;SHEN Hailan(Department of Clinical Laboratory,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院检验科,重庆400016

出　　处：《国际检验医学杂志》2021年第1期121-125,共5页International Journal of Laboratory Medicine

摘　　要：血清中的肌酐水平可反映肾小球滤过功能,是衡量和监测肾功能最常用的指标之一。目前肌酐检测方法已达10余种,但各种方法的结果之间有一定程度的差异,其中特异度和抗干扰能力较强的酶法被临床实验室广泛运用。然而,研究发现一些临床常用药物会对肌酐检测产生干扰,其中羟苯磺酸钙会对酶法检测肌酐产生较为严重的负干扰,导致检测结果与患者临床表现不符,且其干扰机制尚不明确。探究其干扰机制、寻求解决办法是临床一线工作者的重任。Serum creatinine level can reflect glomerular filtration function,which is one of the most commonly used index to measure and monitor renal function.At present,there are more than 10 kinds of methods to detect serum creatinine,but differences between the results of different methods can be easily found.Among them,the enzyme method with high specificity and anti-interference ability is widely used in clinical laboratories.However,studies have found that some commonly used clinical drugs can interfere with creatinine detection,in which the calcium dobesilate will produce a serious negative interference to the enzyme creatinine detection and result in the inconsistence between the detection results and manifestations of patients,and its interference mechanism is not clear.It is an important task for clinical frontline workers to explore its interference mechanism and seek solutions.

关 键 词：羟苯磺酸钙 肌酐 肌氨酸氧化酶法 负干扰 

分 类 号：R446.112[医药卫生—诊断学]