牛磺酸对2型糖尿病患者冠状动脉支架置入术后再狭窄的影响  

Effect of Taurine on Stent Restenosis after PCI in Patients with Type 2 Diabetes

作　　者：康楷湝 孟娜 徐亚楠 王国良 Kang Kaijie;Meng Na;Xu Yanan(Department of Cardiovascular Intensive Care,First Affiliated Hospital of Henan University,Henan 475000,China;不详)

机构地区：[1]河南大学第一附属医院心血管重症,开封475000 [2]河南大学第一附属医院重症医学科,开封475000 [3]河南大学第一附属医院心血管内科,开封475000

出　　处：《医学研究杂志》2021年第1期72-75,共4页Journal of Medical Research

基　　金：河南省医学科技攻关计划项目。

摘　　要：目的探讨牛磺酸对2型糖尿病患者冠状动脉(以下简称冠脉)支架置入术后再狭窄的影响。方法将2017年7月~2019年6月在笔者医院接受治疗的180例冠心病并置入药物洗脱支架的2型糖尿病患者分为对照组和干预组。其中2017年7月~2018年6月入院治疗的患者设定为对照组,采用常规治疗。2018年7月~2019年6月入院治疗的患者设定为干预组,在常规治疗的基础上每天口服牛磺酸片,每天3次,疗程6个月。比较干预后两组患者再狭窄率、再狭窄程度、晚期丢失内径、晚期丢失内径指数、净获得内径、净获得内径指数以及不良事件发生率的差异。结果干预组患者冠状动脉再狭窄发生率低于对照组患者,晚期丢失内径、晚期丢失内径指数低于对照组患者,净获得内径、净获得内径指数高于对照组患者,不良事件发生显著低于对照组患者,各项目差异均有统计学意义(P<0.05)。结论牛磺酸可显著降低2型糖尿病患者冠脉支架置入术后再狭窄发生率,改善临床指标和不良事件发生情况,值得临床推广。Objective To investigate the effect of taurine on stent restenosis after PCI in patients with type 2 diabetes.Methods A total of 180 patients with type 2 diabetes and CHD who implanted with drug-eluting stent(DES)from Jun 2017 to Jul 2019 in our hospital were divided into control group and intervention group.Patients from Jun 2017 to Jun 2018 were enrolled into control and used routine treatment.Patients from Jul 2018 to Jun 2019 were enrolled into intervention group,and took 3 times of taurine tablets orally daily on this basis,the course is 6 months.The difference of restenosis rate,restenosis level,last lumen losing and index,net gain lumen and index,and adverse events rate were compared between two groups.Results The incidence of restenosis in intervention group was significantly lower than that in control group.The last lumen losing and index in intervention group were significantly lower than those in control group.The net gain lumen and index were higher than those in control group.The adverse events rate was significantly lower than that in control group.The difference was all significantly(P<0.05).Conclusion Taurine can significantly reduce restenosis after PCI in patients with type 2 diabetes,improve clinic indexes and adverse events rate,which is worth of clinic promotion.

关 键 词：牛磺酸 2型糖尿病 冠脉支架置入术 再狭窄 

分 类 号：R453.1[医药卫生—治疗学]