血清胸苷激酶1对老年大肠癌的预测及术后监测效果评价  

Significance of Serum Thymidine Kinase 1 in Risk Evaluation and Postoperative Monitoring of Colorectal Cancer in Older Patients

作　　者：穆雪峰 康文全 丁巍 潘红艳 胡元佳 Mu Xuefeng;Kang Wenquan;Ding Wei;Pan Hongyan;Hu Yuanjia(Department of Gastroenterology,Union Shenzhen Hospital,Huazhong University of Science and Technology,Shenzhen 518000)

机构地区：[1]华中科技大学协和深圳医院消化科,深圳581000

出　　处：《国际老年医学杂志》2021年第1期43-45,共3页International Journal of Geriatrics

摘　　要：目的探究血清胸苷激酶1(TK1)对老年人罹患大肠癌风险评估及大肠癌术后监测效果评价的意义。方法选取2015年1月~2016年12月在华中科技大学协和深圳医院体检中心患者80例为实验组,其中包含大肠管状腺瘤、大肠早癌、进展期大肠癌、大肠癌术后复发等类型患者各20例,另选取37例健康体检的老年患者为对照组。比较两组血清中的TK1,大肠癌常规肿瘤标志物血清癌胚抗原(CEA)、癌抗原19-9(CA19-9)表达水平。结果实验组中,大肠早癌、进展期大肠癌、大肠癌术后复发患者TK1明显高于大肠管状腺瘤患者,差异均具有统计学意义(P<0.05),大肠管状腺瘤、大肠早癌、进展期大肠癌、大肠癌术后复发等各组患者联合检测(TK1+CEA+CA19-9)的灵敏度明显高于各单项检测(P<0.05),而特异性差异无统计学意义(P>0.05)。结论TK1可在一定程度上提示大肠癌患者肿瘤增殖速度,可作为一种新型血清学肿瘤标记物对大肠癌患者进行系统监测。Objective To explore the significance of serum thymidine kinase 1(TK1)in risk evaluation and postoperative monitoring of colorectal cancer in older patients.Methods From January 2015 to December 2016,80 patients(including 20 cases of colorectal tubular adenoma,20 cases of early colorectal cancer,20 cases of advanced colorectal cancer,and 20 cases of postoperative recurrence of colorectal cancer)in Union Shenzhen Hospital of Huazhong University of Science and Technology were selected as the experimental group.37 older people undergoing health check-up were selected as the control group.The levels of TK1,carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)in serum were compared between the two groups.Results TK1 level in patients with early colorectal cancer,advanced colorectal cancer and postoperative recurrence of colorectal cancer was significantly higher than that in patients with colorectal tubular adenoma respectively(P<0.05).The sensitivity of joint detection(TK1+CEA+CA19-9)was significantly higher than that of single detection(P<0.05),however,there was no significant difference in specificity(P>0.05).Conclusion TKI might be used as a new serological tumor marker to monitor the patients with colorectal cancer.

关 键 词：胸苷激酶1 大肠癌 肿瘤标志物 

分 类 号：R735.34[医药卫生—肿瘤]