Clinical cure and liver fibrosis reversal after postoperative antiviral combination therapy in hepatitis B-associated non-cirrhotic hepatocellular carcinoma: A case report  

作　　者：Xue-Ping Yu Qi Lin Zhi-Peng Huang Wei-Shan Chen Ming-Hui Zheng Yi-Juan Zheng Ju-Lan Li Zhi-Jun Su 

机构地区：[1]Department of Infection Diseases,First Hospital of Quanzhou Affiliated to Fujian Medical University,Quanzhou 362000,Fujian Province,China [2]Department of Gastroenterology,First Hospital of Quanzhou Affiliated to Fujian Medical University,Quanzhou 362000,Fujian Province,China [3]Department of Pathology,First Hospital of Quanzhou Affiliated to Fujian Medical University,Quanzhou 362000,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2021年第3期714-721,共8页世界临床病例杂志

基　　金：Natural Science Foundation of Fujian Province,No.2019J01593;High-Level Talent Innovation Project of Quanzhou,No.2018C067R;Science and Technology Innovation Joint Project of Fujian Province,No.2019Y9048;Youth Research Project of Fujian Provincial Health Commission,No.2018-1-94 and No.2018-1-95;Science and Technology Project of Quanzhou,No.2018Z074 and No.2018Z069.

摘　　要：BACKGROUND The incidence of hepatocellular carcinoma(HCC)is high in China,and approximately 15%-20%of HCC cases occur in the absence of cirrhosis.Compared with patients with cirrhotic HCC,those with non-cirrhotic HCC have longer postoperative tumor-free survival.However,the overall survival time is not significantly increased,and the risk of postoperative recurrence remains.Strategies to improve the postoperative survival rate in these patients are currently required.CASE SUMMARY A 47-year-old man with a family history of HCC was found to have hepatitis B virus(HBV)infection 25 years ago.In 2000,he was administered lamivudine for 2 years,and entecavir(ETV 0.5 mg)was administered in 2006.In October 2016,magnetic resonance imaging revealed a tumor in the liver(5.3 cm×5 cm×5 cm);no intraoperative hepatic and portal vein and bile duct tumor thrombi were found;and postoperative pathological examination confirmed a grade II HCC with no nodular cirrhosis(G1S3).ETV was continued,and no significant changes were observed on imaging.After receiving pegylated interferon alfa-2b(PEG IFNα-2b)(180μg)+ETV in February 2019,the HBsAg titer decreased significantly within 12 wk.After receiving hepatitis B vaccine(60μg)in 12 wk,HBsAg serological conversion was realized at 48 wk.During the treatment,no obvious adverse reactions were observed,except for early alanine aminotransferase flares.The reexamination results of liver pathology were G2S1,and reversal of liver fibrosis was achieved.CONCLUSION The therapeutic regimen of ETV+PEG IFNα-2b+hepatitis B vaccine for patients with HBV-associated non-cirrhotic HCC following hepatectomy can achieve an HBV clinical cure and prolong the recurrence-free survival.

关 键 词：Hepatocellular carcinoma Hepatitis B virus ENTECAVIR Pegylated interferon alfa-2b Clinical cure Case report 

分 类 号：R512.62[医药卫生—内科学] R735.7[医药卫生—临床医学]