the National Natural Science Foundation of China(No.82305100,82305200,82205052)for their support.
Background/Aims:Traditional Chinese medicine(TCM)combined with antiviral therapy has been proven to be effective for liver fibrosis due to chronic hepatitis B(CHB)in clinical practice in China.However,the robust evide...
supported by grants from Key-Area Research and Development Program of Guangdong Province(No.2020B0101130015);Guangdong Medical Science and Technology Research Fund(No.A2021304);the Natural Science Foundation of China(No.82070611);Guangzhou Science and Technology Plan Projects(No.2023B03J1287);Guangzhou Science and Technology Program Key Projects(No.2023B01J1007);Sun Yat-Sen University Clinical Research 5010 Program(No.2020007);the Five-Year Plan of Third Affiliated Hospital of Sun Yat-sen University(No.2023W106);Clinical trial number:ClinicalTrials.gov ID:NCT03920618.
Background and aims:Antiviral therapy is essential for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).No data are available on the long-term prognosis or safety of tenofovir alafenamide(TAF),tenofo...
supported by the Shanghai Key Specialty of Traditional Chinese Clinical Medicine(grant number shslczdzk01201);the National Science and Technology Major Project(grant number 2018ZX10302204);Shanghai University of Traditional Chinese Medicine(grant number ZYJK FW201811013).
Background and Aims:The application of antifibrotic drugs to treat patients with chronic liver diseases who are receiving antiviral therapies for hepatocellular carcinoma(HCC)has not been established.Here,we aimed to ...
Background:The role of different genotypes in nucleos(t)ide analogs(NAs)treatment is still debated.Previous studies conducted on special populations evidenced that the E genotype had the lower virological and serologi...
This letter comments on the article which reported that tenofovir alafenamide may increase blood lipid levels compared with entecavir in patients with chronic hepatitis B published on World J Hepatol 2023 August 27.We...
Study on the efficacy and safety of tenofovir alafenamide in treating chronic hepatitis B patients with poor entecavir response,No.SKJP22020201008.
BACKGROUND Entecavir(ETV)is a potent and safe antiviral agent for patients with chronic hepatitis B(CHB);however,some patients may exhibit suboptimal response or resistance to ETV.Tenofovir alafenamide(TAF)is a novel ...
Introduction Individual patient data(IPD)meta-analysis by Choi et al.(1)compared hepatocellular carcinoma(HCC)risk between the entecavir(ETV)and tenofovir(TDF)in treatment-naïve chronic hepatitis B(CHB)patients using ...
Chronic hepatitis B(CHB)remains a major global health problem with approximately 258 million infected individuals(1).Hepatocellular carcinoma(HCC)is one of the major and most deadly consequences of CHB.Especially cirr...
supported by grants from the National Natural Science Foundation of China(Nos.81900576,82100650);the Science and Technological Supports Project of Sichuan Province(Nos.2019YJ0149,22ZDYF1593);the Post-Doctor Research Project,West China Hospital,Sichuan University(No.2020HXBH069)
Serum hepatitis B virus deoxyribonucleic acid(HBVDNA)load is a critical index used to reflect the degree of viral replication in hepatocytes and to evaluate host hepatitis viral status.The risk of hepatocellular carci...
Supported by National Science and Technology Major Project,No.2014ZX10005001 and No.2018ZX10302204;National Natural Science Foundation of China,No.81730109 and No.82274305;Shanghai Key Specialty of Traditional Chinese Clinical Medicine,No.shslczdzk01201;China Postdoctoral Science Foundation,No.2022M722162;Siming Youth Fund of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,No.SGKJ-202104.
BACKGROUND After receiving entecavir or combined with FuzhengHuayu tablet(FZHY)treatment,some sufferers with hepatitis B virus(HBV)-related liver fibrosis could achieve a histological improvement while the others may ...