遗传因素与散发性脑小血管病的相关性研究进展  

Research progress on the relationship between genetic factors and cerebral small vessel disease

作　　者：钟美香 徐璐璐 王亚娟 郑雪平[1] Zhong Meixiang;Xu Lulu;Wang Yajuan;Zheng Xueping(Department of Gerontology,the Affiliated Hospital of QingDao University,QingDao 266000,China;Department of Gerontology,the 8th People's Hospital of QingDao,QingDao 266000,China)

机构地区：[1]青岛大学附属医院老年医学科,山东青岛266000 [2]青岛市第八人民医院老年医学科,山东青岛266000

出　　处：《中华脑血管病杂志（电子版）》2020年第6期366-369,共4页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

摘　　要：脑小血管病发病隐匿且机制复杂多样,研究发现散发的脑小血管病同单基因遗传性脑小血管病一样具有遗传易感性,遗传因素在脑小血管病的发生发展中起着不可忽视的作用。本文总结了散发性脑小血管病中的6种影像学表现与遗传因素之间的相关性,包括基因的多态性以及RNA在脑小血管病中的作用。The pathogenesis of cerebral small vessel disease(CSVD)is elusive and the mechanism is complex and diverse.Studies have found that sporadic CSVD has the similar genetic susceptibility as monogenic hereditary CSVD,and genetic factors play an important role in the incidence and development of CSVD.This article summarizes the correlation between six kinds of imaging manifestations and genetic factors in sporadic CSVD,as well as the role of genetic polymorphisms and RNA in CSVD.

关 键 词：脑小血管病 遗传因素 RNA 

分 类 号：R743[医药卫生—神经病学与精神病学]