CREPT在人脑胶质母细胞瘤组织中的表达及其与病人预后的关系  

Expression of CREPT in human glioblastoma tissues and its relationship with patients'prognoses

作　　者：王睿健 张文超 尹涛 WANG Rui-jian;ZHANG Wen-chao;YIN Tao(Department of Neurosurgery,People's Hospital of Hengshui City,Hengshui 053000,China)

机构地区：[1]衡水市人民医院神经外科,河北053000

出　　处：《中国临床神经外科杂志》2021年第1期20-22,25,共4页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨人脑胶质母细胞瘤(GBM)组织肿瘤高表达细胞周期相关蛋白(CREPT)的表达水平及其与病人预后的关系。方法收集2010年1月至2011年1月手术切除的GBM组织104例和2018年1~12月颅脑损伤内减压术中切除的正常脑组织40例,采用免疫组织化学染色法检测CREPT的表达,根据染色情况将GBM分为高表达组和低表达组。GBM病人术后随访截止时间为2019年4月,记录总生存期(OS)和无进展生存期(PFS)。采用多因素Cox比例回归风险模型分析GBM病人生存预后的影响因素。用Kaplan-Meier法绘制生存曲线,采用Log-rank检验。结果GBM组织CREPT高表达率(73.08%,76/104)明显高于正常脑组织(10.00%,4/40;P<0.05)。多因素Cox比例回归风险模型分析结果显示CREPT高表达是GBM病人OS和PFS较短的独立影响因素(P<0.05)。低表达组OS和PFS均明显高于高表达组(P<0.05)。结论人脑GBM组织CREPT呈高表达,与病人不良生存预后和肿瘤进展有关。Objective To investigate the expression of cell cycle-related and expression elevated protein in tumor(CREPT)in human glioblastoma(GBM)tissues and its relationship with patients'prognoses.Methods The expressions of CREPT in GBM tissues obtained from 104 patients with GBM who underwent microsurgery from January 2010 to January 2011 and in normal cerebral tissues obtained from 40 patients with traumatic brain injury who underwent decompression were detected by immunohistochemistry.According to the staining,the level of CREPT expression were divided into high expression and low expression.The deadline for postoperative follow-up of GBM patients was April 2019,and overall survival(OS)and progression-free survival(PFS)were recorded.Results The high expression rate of CREPT in GBM tissues(73.08%,76/104)was significantly higher than that(10.00%,4/40)in normal brain tissues(P<0.05).Multivariate Cox proportional regression risk model analysis showed that high expression of CREPT was an independent risk factor for shorter OS and PFS in GBM patients(P<0.05).OS and PFS of GBM patients in the low expression group were significantly higher than those in the high expression group(P<0.05).Conclusion CREPT is highly expressed in human GBM tissues,which is related to the poor survival prognosis and tumor progression in GBM patients.

关 键 词：胶质母细胞瘤 肿瘤高表达细胞周期相关蛋白 CREPT 预后 基因表达 

分 类 号：R739.41[医药卫生—肿瘤] Q786[医药卫生—临床医学]