细胞程序性死亡与炎症发生  

Programmed Cell Death and Inflammation

作　　者：陈梦 戴海明 CHEN Meng;DAI Haiming(Center of Pathology and Laboratory Medicine,Hefei Cancer Hospital,Chinese Academy of Sciences,Hefei 230031,China;Anhui Province Key Laboratory of Medical Physics and Technology,Institute of Health&Medical Technology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学院合肥肿瘤医院医学病理中心,合肥230031 [2]中国科学院合肥物质科学研究院健康与医学技术研究所医学物理与技术安徽省重点实验室,合肥230031 [3]中国科学技术大学,合肥230026

出　　处：《中国细胞生物学学报》2020年第12期2205-2214,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:21703254、21772201);安徽医科大学与医学物理与技术中心联合基金(批准号:LHJJ202006、LHJJ202007)资助的课题。

摘　　要：细胞死亡是机体内发生的一种普遍的生物学过程,在机体的生长发育过程中起重要作用,并与多种疾病的发生发展相关。而炎症则是机体对于损伤因子等刺激产生的一种免疫防御反应。适当的炎症可以刺激并提高机体免疫力,过度的炎症则对机体产生持续的损伤,甚至危及生命。传统意义上来讲,导致炎症发生的细胞死亡方式是坏死。近年来却发现,包括凋亡在内的多种细胞程序性死亡在一定程度上都与炎症发生有关。该文就不同细胞程序性死亡的分子机制及其在炎症发生中的作用的研究进展作综述,旨在为相关科学问题研究提供思路。Cell death is a common biological process that plays an important role in the growth and development of the body.Moreover,cell death is related to the development of many diseases.Inflammation is an immune defense response to stimuli of injury factors.Appropriate inflammation can stimulate and improve the body’s immunity.However,excessive inflammation will cause continuous damage to the body,even life-threatening.Traditionally,the cell death that causes inflammation is necrosis.Recently,it has been found that a variety of programmed cell death,including apoptosis,are related to the development of inflammation to a certain extent.This review summarizes the recent progress in the understanding of molecular mechanisms of different programmed cell death and their roles in inflammation,which aims to provide ideas for the research of related scientific issues.

关 键 词：细胞程序性死亡 凋亡 坏死性凋亡 焦亡 炎症 

分 类 号：R364.5[医药卫生—病理学]