放疗促进肿瘤转移的研究进展  

Research progress of radiotherapy-induced tumor metastasis

作　　者：曹玉霖 殷媛[1] 李杰[2] 周乐源[1] Cao Yulin;Yin Yuan;Li Jie;Zhou Leyuan(Oncology Institute,the Affiliated Hospital of Jiangnan University,Wuxi 214062,China;Department of Interventional,the Affiliated Hospital of Jiangnan University,Wuxi 214062,China)

机构地区：[1]江南大学附属医院肿瘤研究所,无锡214062 [2]江南大学附属医院介入科,无锡214062

出　　处：《国际放射医学核医学杂志》2020年第9期589-593,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金青年科学基金项目(81301920);无锡市医学重点人才项目(ZDRC013)。

摘　　要：肿瘤细胞从原发病灶迁移到远处部位形成转移病灶的过程增加了患者的病死率。放疗可通过电离直接或通过产生活性氧间接导致DNA损伤,从而杀死肿瘤细胞。然而,近年来的研究结果表明,放疗诱导的肿瘤微环境变化在某些情况下可促进肿瘤转移而导致治疗失败。放疗后肿瘤微环境变化与肿瘤转移的关系受到广泛关注,但其机制尚不明确。笔者对放疗如何通过诱导细胞因子表达、缺氧、整合素表达水平升高以及外泌体变化等因素从而促进肿瘤的转移进行综述。The process of tumor cells migrating from the primary lesion to distant sites to form metastatic lesions increases the mortality of patients.Radiotherapy can cause DNA damage directly through ionization or indirectly through the production of reactive oxygen species,thereby destroying tumor cells.However,recent studies have shown that radiotherapy-induced changes in tumor microenvironment can promote tumor metastasis and cause treatment failure in some cases.The relationship between tumor microenvironment changes after radiotherapy and tumor metastasis has received widespread attention,but the mechanism remains unclear.This review discusses how radiotherapy promotes tumor metastasis by inducing cytokine expression,hypoxia,increased integrin expression and changes in exosome.

关 键 词：放射疗法 肿瘤微环境 肿瘤转移 

分 类 号：R730.55[医药卫生—肿瘤]