Concentration of circulating microparticles:a new biomarker of acute heart failure after cardiac surgery with cardiopulmonary bypass  

作　　者：Yuquan Li Haoxiang Yuan Caiyun Chen Chao Chen Jian Ma Yating Chen Yan Li Yupeng Jian Donghong Liu Zhijun Ou Jingsong Ou 

机构地区：[1]Division of Cardiac Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China [2]National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases,Guangzhou,510080,China [3]NHC key Laboratory of Assisted Circulation,Sun Yat-sen University,Guangzhou,510080,China [4]Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases,Guangzhou,510080,China [5]Department of Anesthesiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China [6]Department of Ultrasound,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China [7]Division of Hypertension and Vascular Diseases,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China [8]Guangdong Provincial Key Laboratory of Brain Function and Disease,Guangzhou,510080,China

出　　处：《Science China(Life Sciences)》2021年第1期107-116,共10页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(81670392,81600382,81770241,81830013,81970363);the National Science Fund for Distinguished Young Scholars(81325001);the International Cooperation Project(2015DFA31070)from the Ministry of Science and Technology of China;the National Key Research and Development Program of China(2016YFC0903000);the Changjiang Scholars Program from the Ministry of Education of China,Guangdong Natural Science Fund Committee(2015A030312009);the Guangdong Pearl River Scholars Program;the Sun Yat-sen University Clinical Research 5010 Program(2014002)。

摘　　要：Acute heart failure(AHF)is a severe complication after cardiac surgery with cardiopulmonary bypass(CPB).Although some AHF biomarkers have been used in clinic,they have limitations when applied in the prediction and diagnosis of AHF after cardiac surgery with CPB,and there are still no effective and specific biomarkers.We and other researchers have shown that circulating microparticles(MPs)increased in a variety of cardiovascular diseases.However,whether the concentration of circulating MPs could be a new biomarker for AHF after cardiac surgery remains unknown.Here,90 patients undergoing cardiac surgery with CPB and 45 healthy subjects were enrolled.Patients were assigned into AHF(n=14)or non-AHF(n=76)group according to the diagnosis criteria of AHF.The concentrations of circulating MPs were determined before,as well as 12 h and 3 days after operation with nanoparticle tracking analysis technique.MPs concentrations in patients before surgery were significantly higher than those of healthy subjects.Plasma levels of MPs were significantly elevated at 12 h after surgery in patients with AHF,but not in those without AHF,and the circulating MPs concentrations at 12 h after surgery were higher in AHF group compared with non-AHF group.Logistic regression analysis indicated that MPs concentration at postoperative 12 h was an independent risk factor for AHF.The area under receiver operating characteristic curve for MPs concentration at postoperative 12 h was 0.87 and the best cut-off value is 5.20×10~8 particles mL~(–1)with a sensitivity of 93%and a specificity of 70%.These data suggested that the concentration of circulating MPs might be a new biomarker for the occurrence of AHF after cardiac surgery with CPB.

关 键 词：MICROPARTICLES CONCENTRATION acute heart failure cardiopulmonary bypass BIOMARKER 

分 类 号：R654.2[医药卫生—外科学]