3-溴-5-乙炔基苯甲酸的合成  

Synthesis of 3-Bromo-5-ethynylbenzoic Acid

作　　者：李舂龙[1] 丁惠芸 路顺达 张琦 张文 王继海 班雅美 LI Chonglong;DING Huiyun;LU Shunda;ZHANG Qi;ZHANG Wen;WANG Jihai;BAN Yamei(School of Chemistry and Chemical Engineering,North Minzu University,Yinchuan 750021,China)

机构地区：[1]北方民族大学化学与化学工程学院,宁夏银川750030

出　　处：《化工技术与开发》2020年第12期5-6,共2页Technology & Development of Chemical Industry

基　　金：北方民族大学科研启动项目(2020KYQD11);2020年校级大学生创新训练计划项目(2020-XJ-HG-017)。

摘　　要：本文以3,5-二溴苯甲酸为原料,通过酯化反应、Sonogashira反应、酯水解及脱保护反应,得到3-溴代-5-乙炔基苯甲酸,各步反应的收率分别是94.7%、69.3%、94.8%。3-Bromo-5-ethynylbenzoic acid was prepared by esterification reaction, Sonogashira coupling reaction, ester decomposition and deprotection used 3,5-dibromobenzoic acid as starting material. The yields of the three steps were 94.7%, 69.3% and 94.8%, respectively.

关 键 词：SONOGASHIRA反应 3-溴-5-乙炔苯甲酸 合成 

分 类 号：O623.61[理学—有机化学]