手术后中性粒细胞/淋巴细胞比例及血小板/淋巴细胞比例与非小细胞肺癌患者预后的相关性  

Relationship of post-operative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with prognosis in patients with non-small cell lung cancer

作　　者：王天辰 秦克秀[2] 王荣[1] 卜丽佳[1] WANG Tian-chen;QIN Ke-xiu;WANG Rong;BU Li-jia(Department of Oncology,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230032,China;Health Managementy Checkup Center,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]安徽医科大学第一附属医院肿瘤内科,安徽合肥230032 [2]安徽医科大学第一附属医院健康管理(体检)中心,安徽合肥230032

出　　处：《临床肺科杂志》2021年第2期245-250,共6页Journal of Clinical Pulmonary Medicine

摘　　要：目的关注中性粒细胞/淋巴细胞比例(Neutrophil-to-Lymphocyte Ratio,NLR)及血小板/淋巴细胞比例(Platelet-to-Lymphocyte Ratio,PLR)与接受手术并行化疗的Ⅰb-Ⅲa期非小细胞肺癌(Non-small cell lung cancer,NSCLC)患者生存时间之间关系。方法本文回顾性研究138例符合入组条件的NSCLC患者,应用Kaplan-Meier曲线行生存分析并进行单因素及多因素分析了解手术前后NLR、PLR与NSCLC患者预后的相关性。结果本文最长随访时间为3661天,平均随访时间2250天。术前NLR≥2.28组(仅OS:P<0.05)、术后NLR≥2.05组、NLR变化≥0组及术后PLR≥122.38组NSCLC患者DFS及OS均明显短于低值组,结果有统计学意义(P<0.05)。亚组分析示NLR术后相比术前升高与患者预后不佳相关(P<0.05);针对PLR术前术后变化进行分析时未能得到有统计学意义的结果(P>0.05);综合分析术后NLR、PLR发现,NLR、PLR均属高值组的总生存时间较低值组短,结果存在统计学意义(P<0.05)。单因素分析示术前NLR、术后NLR、术后PLR及NLR变化是NSCLC患者预后的影响因素(P<0.05);多因素分析显示术前NLR、术后NLR、术后PLR是手术后NSCLC患者预后的独立预测因素(P<0.05)。结论术后NLR及PLR与NSCLC患者预后有显著相关性,术后NLR、PLR高值组患者预后明显差于低值组。Objective To focus on the relationship of the ratio of neutrophil to lymphocyte(NLR)and platelet to lymphocyte ratio(PLR)with the survival time of patients with non-small cell lung cancer(NSCLC)who underwent lobotomy combined with hilar and mediastinal lymph node dissection.Methods A retrospective study was conducted on 138 NSCLC patients who met the inclusion criteria.Survival analysis was performed by K-M method and univariate and multivariate analyses were performed to analyze the correlation between different clinical characteristics.Results The longest follow-up time was 3661 days,and the average follow-up time was 2250 days.The DFS and OS of NSCLC patients in the preoperative NLR≥2.28 group(OS only:P<0.05),the postoperative NLR≥2.05 group,the NLR change≥0 group and the postoperative PLR≥122.38 group were significantly shorter than those in the low-value group,and the results were statistically significant(P<0.05).Subgroup analysis showed that the increase of NLR after operation compared with that before operation was associated with poor prognosis(P<0.05).The changes of PLR did not have any statistically significant results(P>0.05).After comprehensive analysis of postoperative NLR and PLR,the total survival time of the high-value group was shorter than the low-value group,with statistically significant results(P<0.05).Univariate analysis showed that preoperative NLR,postoperative NLR,postoperative PLR and NLR changes were influencing factors for the prognosis of NSCLC patients(P<0.05).Multivariate analysis showed that preoperative NLR,postoperative NLR and postoperative PLR were independent predictors of the prognosis of NSCLC patients after surgery(P<0.05).Conclusion Postoperative NLR and PLR have predictive value for the NSCLC patients undergoing lobectomy combined with hilar and mediastinal lymph node dissection.

关 键 词：非小细胞肺癌 术后NLR 术后PLR 无病生存时间 总生存时间 

分 类 号：R734.2[医药卫生—肿瘤]