IGF-Ⅰ EGFR在子宫组织的表达及与肌瘤复发的关系  

Expression of IGF-Ⅰ and EGFR in Uterine Tissues and Their Relationship with Recurrence of Leiomyoma

作　　者：颜红丽 郑丽华 白昌民 邵美丽 YAN Hongli;ZHENG Lihua;BBAI Changmin(Northwest Women and Children's Hospital / Shaanxi Maternal and Child Health Hospital, Shanxi Xi'an 710061, China)

机构地区：[1]西北妇女儿童医院/陕西省妇幼保健院妇产科,陕西西安710061

出　　处：《河北医学》2021年第1期116-121,共6页Hebei Medicine

基　　金：陕西省科学技术研究发展计划项目,(编号:2019K12-01)。

摘　　要：目的:探讨胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、表皮生长因子受体(EGFR)在子宫组织中的表达及与肌瘤复发的关系。方法:回顾性分析2018年1月至2018年12月于医院行子宫肌瘤剔除术的125例子宫肌瘤患者临床资料。采用免疫组化法检测患者子宫肌瘤组织、瘤旁组织、子宫肌层组织中的IGF-Ⅰ、EGFR表达情况。术后随访1年,根据肌瘤是否复发分为复发组(37例)和未复发组(88例)。分析并比较两组患者3种子宫组织中的IGF-Ⅰ、EGFR表达情况。结果:IGF-Ⅰ、EGFR在不同子宫组织中的表达情况比较,差异具有统计学意义(P<0.05)。复发组患者肌瘤组织、瘤旁组织、肌层组织中的IGF-Ⅰ、EGFR表达情况均高于未复发组患者,差异具有统计学意义(P <0.05)。结论:IGF-Ⅰ、EGFR在子宫肌瘤患者肌瘤组织中的表达水平高于瘤旁组织及肌层组织,且IGF-Ⅰ、EGFR的表达强度增强可能为肌瘤复发的潜在因素之一。Objective: To investigate the expression of insulin-like growth factor-Ⅰ( IGF-Ⅰ) and epidermal growth factor receptor( EGFR) in uterine tissues and their relationship with myoma recurrence. Methods: The clinical data of 125 patients with hysteromyoma who underwent myomectomy from January 2018 to December 2018 were analyzed retrospectively. The expression of IGF-Ⅰ and EGFR in myoma,Paratumor and myometrium were detected by immunohistochemistry. After 1 year follow-up,the patients were divided into recurrence group( 37 cases) and nonrecurrence group( 88 cases). The expression of IGF-Ⅰ and EGFR in three kinds of uterine tissues of the two groups were analyzed and compared. Results: The expression of IGF-Ⅰ and EGFR in different uterine tissues was statistically significant( P <0.05). The expression of IGF-Ⅰ and EGFR in myoma,Paratumor and myometrium of patients with recurrence was higher than that of patients without recurrence( P <0.05). Conclusion: The expression level of IGF-Ⅰ and EGFR in the myoma of patients with uterine leiomyoma is higher than that in the adjacent tissue and myometrium,and the increased expression intensity of IGF-Ⅰ and EGFR may be one of the potential factors for the recurrence of myoma.

关 键 词：胰岛素样生长因子-Ⅰ 表皮生长因子受体 子宫组织 子宫肌瘤复发 免疫组织化学法 

分 类 号：R737.33[医药卫生—肿瘤]