血清肿瘤相关标志物在肺鳞癌中的表达水平与预后的关系  

Expression levels of serum CEA,SCCA,ProGRP and CYFRA21-1 in lung squamous cell carcinoma and their relationship with the prognosis

作　　者：李燕舞[1] 殷俊[1] 梁秋萍[1] 李艳萍[1] 高航[1] LI Yanwu;YIN Jun;LIANG Qiuping;LI Yanping;GAO Hang(Department of Respiratory and Critical Care Medicine, Chengdu Third People's Hospital, Chengdu 610031, China)

机构地区：[1]成都市第三人民医院呼吸与危重症医学科,四川成都610031

出　　处：《西部医学》2021年第1期84-88,共5页Medical Journal of West China

基　　金：北京医卫健康公益基金(YWJKJJHKYJJ-F3228D)。

摘　　要：目的探讨血清癌胚抗原(CEA)、鳞状细胞癌抗原(SCCA)、胃泌素释放肽前体(ProGRP)、细胞角蛋白19片段(CYFRA21-1)在肺鳞状细胞癌(SQC)中的表达情况,并分析与预后关系。方法选取2015年1月~2017年6月期间我院SQC患者(SQC组)、肺部良性病变(良性病变组)与同期体检健康者(对照组)各80例,比较3组血清CEA、SCCA、ProGRP、CYFRA21-1水平,并分析其与SQC患者病理特征及预后关系。结果SQC组血清CEA、SCCA、ProGRP、CYFRA21-1表达水平显著高于良性病变组与对照组(P<0.05),良性病变组与对照组比较差异无统计学意义(P>0.05);TNM分期Ⅲ~Ⅳ期、有淋巴结转移、浸润程度T3~T4患者CEA、SCCA、ProGRP、CYFRA21-1高表达率明显高于TNM分期Ⅰ~Ⅱ、无淋巴结转移、浸润程度T1~T2患者(P<0.05);多元无序logistics分析显示,血清CEA、SCCA、ProGRP及CYFRA21-1为SQC独立危险因素(P<0.05);Kaplan-Meier生存分析显示,CEA、SCCA、ProGRP、CYFRA21-1高表达总体生存率明显小于低表达患者(P<0.05)。结论SQC患者存在血清CEA、SCCA、ProGRP、CYFRA21-1表达水平升高趋势,且与肿瘤分期、淋巴结转移、浸润程度有关,可用于评估患者预后。Objective To observe the expression of serum carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCCA),pro-gastrin-releasing peptide(ProGRP)and cytokeratin 19 fragment(CYFRA21-1)in pulmonary squamous cell carcinoma(SQC)and analyze their relationship with the prognosis.Methods 80 patients with SQC(SQC group),80 patients with benign benign pulmonary lesions(benign lesion group),and 80 healthy patients(control group)were selected as the subjects.Serum CEA,SCCA,ProGRP and CYFRA 21-1 levels were compared among the three groups,and their relationships with pathological characteristics and prognosis of SQC were analyzed.Results The serum levels of CEA,SCCA,ProGRP and CYFRA2111 in SQC group were significantly higher than those in benign lesion group and control group(P<0.05).There was no significant difference between benign lesion group and control group(P>0.05).The high expression rates of CEA,SCCA,ProGRP and CYFRA21-1 in patients with TNM stageⅢ-Ⅳ,lymph node metastasis and infiltration degree T3-T4 were significantly higher than those in TNM stageⅠ-Ⅱ,no lymph node metastasis and infiltration degree T1-T2(P<0.05).Multivariate logistic analysis showed that serum CEA,SCCA,ProGRP and CYFRA21-1 were independent risk factors for SQC(P<0.05).Kaplan Meier survival analysis showed that the overall survival rate of patients with high expression of CEA,SCCA,ProGRP and CYFRA21-1 was significantly lower than that of patients with low expression(P<0.05).Conclusion The expression levels of serum CEA,SCCA,ProGRP and CYFRA21-1 show an increasing trend in patients with SQC,and they are related to tumor stage,lymph node metastasis and infiltration degree.They can be used to evaluate the prognosis of patients.

关 键 词：肺鳞癌 癌胚抗原 鳞状细胞癌抗原 胃泌素释放肽前体 细胞角蛋白19片段 

分 类 号：R734.2[医药卫生—肿瘤]