18F-FDG PET/CT最大标准摄取值与局部晚期乳腺癌临床病理特征及预后的相关性  

18F-FDG PET/CT SUVmax and clinicopathological features of locally advanced breast cancer and its correlation with prognosis

作　　者：曹林 陈晓良 李倩[2] CAO Lin;CHEN Xiao-liang;LI Qian(Department of Nuclear Medicine,Chongqing University Cancer Hospital,Chongqing 400030,China;Department of Nuclear Medicine,Chongqing University Central Hospital/Chongqing Emergency Medical Center,Chongqing 400030,China)

机构地区：[1]重庆大学附属肿瘤医院核医学科,重庆400030 [2]重庆大学附属中心医院/重庆市急救医疗中心核医学科,重庆400030

出　　处：《东南国防医药》2021年第1期28-31,共4页Military Medical Journal of Southeast China

基　　金：重庆市科学技术委员会自然科学基金(cstc2018jcyjAX0819)。

摘　　要：目的探讨18 F-脱氧葡萄糖(18 F-FDG)正电子发射计算机断层扫描(PET/CT)最大标准摄取值(SUVmax)与局部晚期乳腺癌(LABC)临床病理特征及预后的相关性。方法选取2017年7月至2019年10月收治的154例LABC患者,均行18 F-FDG PET/CT检查,比较不同病理特征及预后患者SUVmax,分析SUVmax预测患者预后的价值。结果肿瘤最大径≥3 cm、组织学分级低分化、T分期T3~T4、Ki-67≥14%、淋巴结转移者,其SUVmax高于肿瘤最大径<3 cm、组织学分级中高分化、T分期T1~T2、Ki-67<14%、无淋巴结转移者(P<0.05)。化疗效果无效者SUVmax(4.13±0.95)低于有效者(5.54±1.34),未完全缓解者SUVmax(4.57±1.12)亦低于完全缓解者(5.70±1.39),差异均有统计学意义(P<0.05)。SUVmax≥4.87组无事件生存率低于SUVmax<4.87组,差异有统计学意义(P<0.05)。Cox回归分析示,肿瘤最大径≥3 cm、组织学分级低分化、T分期T3~T4、Ki-67≥14%、淋巴结转移、SUVmax≥4.87是影响LABC患者预后的危险因素(P<0.05)。结论18 F-FDG PET/CT SUVmax与LABC肿瘤最大径、组织学分级、T分期、Ki-67及淋巴结转移有关,随着SUVmax的升高,患者对化疗的反应增强,但术后无事件生存期更短。Objective To study the maximum standard uptake value(SUVmax)of 18 F-fluorodeoxy glucose(18 F-FDG)Positron emission tomograpgy/computed tomography(PET/CT)and local advanced breast cancer(LABC),and to explore the clinicopathological characteristics of cancer and the correlation with prognosis.Methods A tatal of 154 LABC cases admitted from July 2017 to October 2019 were examined by 18 F-FDG PET/CT.SUVmax was compared with different pathological features and prognosis,and the prognostic value of SUVmax was analyzed.Results The SUVmax of patients with tumor maximum diameter≥3 cm,low differentiation of histological grade,T stage T3-T4,Ki-67≥14%,lymph node metastasis was higher than that of patients with tumor maximumdiameter<3 cm,high differentiation of histological grade,T stage T1-T2,Ki-67<14%,no lymph node metastasis(P<0.05).The SUVmax of ineffective patients(4.13±0.95)was lower than that of effective patients(5.54±1.34)(P<0.05).The SUVmax(4.57±1.12)of incomplete remission was also lower than that of complete remission(5.70±1.39)(P<0.05).The mean value of SUVmax of 154 patients with LABC was 4.87.The patients were included into SUVmax≥4.87 group(n=77),SUVmax<4.87 group(n=77),and the event-free survival rate of SUVmax≥4.87 group was lower than that of SUVmax<4.87 group(P<0.05).Cox regression analysis showed that the risk factors(P<0.05)for the prognosis of patients with LABC were tumor diameter≥3 cm,histological grade low differentiation,T stage T3-T4,Ki-67≥14%,lymph node metastasis,SUVmax≥4.87.Conclusion 18 F-FDG PET/CT SUVmax is associated with the largest diameter,histological grade,T-stage,Ki-67 and lymph node metastasis of LABC.With the increase of SUVmax,the response of patients to chemotherapy is enhanced,but the postoperative event-free survival period is shorter.

关 键 词：18 F-脱氧葡萄糖 正电子发射计算机断层扫描 局部晚期乳腺癌 病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]