α-烯醇化酶在肿瘤发生发展中的作用机制研究进展  

Research progress on the role and mechanism of alpha-enolase in tumorigenesis and development

作　　者：蔡鑫 梁婷(综述) 罗岳西(审校)[1] CAI Xin;LIANG Ting(reviewing);LUO Yue-xi(checking)(Department of Obstetrics and Gynecology,Nanchong Central Hospital,The Second Clinical Medical College,North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院第二临床医学院(南充市中心医院)妇产科,南充637000

出　　处：《东南国防医药》2021年第1期50-53,共4页Military Medical Journal of Southeast China

基　　金：四川省科学技术厅科技计划项目(2016JY0155);四川省教育厅科研计划项目(16ZA0239);南充市校科技战略合作项目(18SXHZ0361)。

摘　　要：肿瘤的发生、发展是一个多基因、多因素、多阶段相互作用的结果。α-烯醇化酶(ENO1)是一种多功能酶,参与多种生理及病理过程,尤其与肿瘤的发生、发展密切相关。研究已证实,ENO1在多种恶性肿瘤中均有不同程度的表达上调,并阐明了部分可能的分子机制。因此,ENO1有望成为一些肿瘤的早期诊断、判断预后的潜在生物标志物和新的治疗靶点。文章主要就ENO1在肿瘤发生发展中的作用及其相关机制的研究进行综述。The occurrence and development of tumors are the product of a multi-gene,multi-factor,multi-stage interaction.Alpha-enolase(ENO1)is a multifunctional enzyme that participates in various physiological and pathological processes,especially closely associated with the genesis and development of tumors.Studies have confirmed that ENO1 is up-regulated in various malignancies to vary degrees,and some possible molecular mechanisms have been elucidated.In this paper,the research progress of ENO1 in tumor is reviewed,which provides theoretical reference and a basis for further clinical research.

关 键 词：α-烯醇化酶 肿瘤 上皮间质转化 侵袭 转移 

分 类 号：R73[医药卫生—肿瘤]