Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(Ⅱ)metallacycle-loaded biomimic melanin dots  

作　　者：Chonglu Li Pei-Pei Jia Yu-Ling Xu Feng Ding Wen-Chao Yang Yao Sun Xiao-Peng Li Guang-Qiang Yin Lin Xu Guang-Fu Yang 

机构地区：[1]Key Laboratory of Pesticide&Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University,Wuhan 430079,China [2]Shanghai Key Laboratory of Green Chemistry and Chemical Processes,School of Chemistry and Molecular Engineering,East China Normal University.Shanghai 200062,China [3]Department of Chemistry,University of South Florida,Tampa 33620,USA

出　　处：《Science China Chemistry》2021年第1期134-142,共9页中国科学（化学英文版）

基　　金：the National Key Research and Development Program(2017YFA0505203);the National Natural Science Foundation of China(21672070);the Fundamental Research Funds for the Central Universities;the Opening Projects of Shanghai Key Laboratory of Green Chemistry and Chemical Processes。

摘　　要：Pt(Ⅱ)-based metallacycles,as an important family of supramolecular coordination complexes(SCCs),have exhibited excellent antitumor activity at the cell level.However,the biomedical applications of Pt(Ⅱ)-based metallacycles for animal studies are still hindered by their poor stability,non-targeted tumour,and lack of detectable feedback for evaluating therapeutic progress.Herein,we propose a strategy that introduces melanin dots as a biomedical platform to load bright-emission Pt(Ⅱ)-based metallacycles,thereby constructing a theranostic agent that enables photoacoustic imaging(PAI)-guided chemo-photothermal combinational therapy.Melanin dots act as a protective carrier to preserve the integrity of Pt(Ⅱ)-based metallacycles before uptake by tumour tissues.Meanwhile,the PAI signal from melanin dots furnishes more comprehensive information on the tumour.Moreover,the heat generated after NIR laser irradiation can not only trigger the apoptosis of tumour cells but also promote the deeper penetration of Pt(Ⅱ)-based SCCs into tumour tissue,thus enhancing the efficiency of chemotherapy.

关 键 词：METALLACYCLES supramolecular coordination complexes chemo-photothermal therapy photoacoustic imaging melanin dots 

分 类 号：R73-36[医药卫生—肿瘤] O641.4[医药卫生—临床医学]