单相抑郁和双相抑郁睡眠特征比较分析  

Analysis of sleep characteristics between major depressive disorder and bipolar depression

作　　者：黄秦特 胡莺燕[1] 周千 吕洞宾 周霓 钱诺诗 黄海婧 吴政霖 洪武[1] HUANG Qinte;HU Yingyan;ZHOU Qian;LYU Dongbin;ZHOU Ni;QIAN Nuoshi;HUANG Haijing;WU Zhenglin;HONG Wu(Shanghai Mental Health Center,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《中国神经精神疾病杂志》2020年第10期608-611,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市卫生和计划生育委员会科研课题项目(编号:201740115);国家自然科学基金项目(编号:81701344);国家重点研发计划资助项目(编号:2016YFC0906300)。

摘　　要：目的运用基于心肺耦合分析的睡眠质量评估系统,比较单相抑郁患者、双相抑郁患者和正常对照睡眠特征的差异。方法招募单相抑郁障碍患者99例、双相障碍抑郁相患者78例、正常对照208名。使用心肺耦合分析睡眠质量评估系统采集受试者的睡眠总体状况、睡眠结构、睡眠生理指标等。结果单相抑郁组的在床总时间和睡眠总时间均较对照组长(P<0.05)。单相抑郁组与双相抑郁组在床总时间无统计学差异(P>0.05),而双相抑郁组睡眠总时间短于单相抑郁组(P<0.05)。单相和双相抑郁组的熟睡心率、浅睡心率、快速动眼睡眠心率、觉醒睡眠心率及呼吸紊乱睡眠心率值均大于对照组(P<0.05),低通气呼吸指数(apnea-hypopnea index,AHI)与对照组无统计学差异(P>0.05)。结论单、双相抑郁患者的在床总时间均长于正常对照,单相抑郁比双相抑郁患者需要更长的睡眠时间。单双相抑郁患者的睡眠各时期均存在心率增快现象,二者存在相似的自主神经功能紊乱症状。Objective This study aimed to compare the differences of sleep characteristics among major depressive disorder,bipolar depression and control group using sleep quality assessment system based on cardiopulmonary coupling analysis.Methods Ninety-nine patients with major depressive disorder,78 patients with bipolar depression and 208 healthy subjects were recruited.The sleep quality assessment system was used to collect the general sleep status,sleep structure and sleep physiological indexes of the subjects.Results Compared with the control group,the total time spent in bed and the total time spent asleep were longer in patients with major depressive depression(P<0.05).There was no significant difference in the total bed time of patients with major depressive disorder and bipolar depression,but the total sleep time of patients with bipolar depression was shorter than that of patients with major depressive disorder(P<0.05).The heart rates of patients with major depressive disorder and bipolar disorder in light sleep,rapid eye movement sleep,wakefulness sleep and aspiration sleep were higher than those of healthy controls(P<0.05).There was no significant difference in Apnea-Hypopnea Index(AHI)between major depressive disorder and bipolar depression patients and healthy controls(P>0.05).Conclusion Both unipolar and bipolar depression patients had longer total time in bed than healthy controls.Compared with major depressive disorder,patients with bipolar depression need longer total sleep time.The heart rate of patients with major depressive disorder and bipolar depression increased,while their autonomic nervous dysfunction was similar during sleep.

关 键 词：抑郁障碍 双相障碍 睡眠质量 心肺耦合分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]