氨基葡萄糖微生物合成研究进展  

Research Progress of Glucosamine Microbial Synthesis

作　　者：李旭[2] 李康 汪俊卿 隋松森[3] 王建彬 郭传庄 李丕武 LI Xu;LI Kang;WANG Jun-qing;SUI Song-sen;WANG Jian-bin;GUO Chuan-zhuang;LI Pi-wu(State Key Laboratory of Bio-based Materials and Green Papermaking,(Shandong Acadeng of Sciences)Qilu University of Technology,Jinan 250353,China;Shandong Key Laboratory of Microbial Engineering,Jinan 250353,China;Zhucheng Dongxiao Biotechnology Co Ltd,Zhucheng 262200,China)

机构地区：[1]山东省微生物工程重点实验室,济南250353 [2]齐鲁工业大学(山东省科学院)生物基材料与绿色造纸国家重点实验室,济南250353 [3]诸城东晓生物科技有限公司,诸城262200

出　　处：《齐鲁工业大学学报》2021年第1期19-22,共4页Journal of Qilu University of Technology

基　　金：国家自然科学基金(31801527);山东省重点研发计划(2019JZZY011003、2018YFJH0401);泰山产业领军人才(tscy20180103);山东省合成生物技术创新中心培育项目(sdsynbio-2018-PY-02);山东省自然科学基金重点项目(ZR2017ZB0208)。

摘　　要：氨基葡萄糖简称氨糖,是葡萄糖的一个羟基被氨基取代后的产物。氨基葡萄糖与其代谢产物乙酰氨基葡萄糖广泛应用于食品、化妆品以及医药行业。随着生物技术的发展,氨基葡萄糖的生产方式由传统的酸解几丁质法转变为微生物发酵法。文章介绍了近年来利用微生物发酵法生产氨基葡萄糖时使用的基因工程技术手段与代谢途径的理性设计方法,讨论了氨基葡萄糖的生产方式和产量,对氨基葡萄糖的进一步生产具有一定的指导意义。Glucosamine is called glucosamine,which is the product of a hydroxyl group of glucose substituted with amino group.Glucosamine and its metabolite acetylglucosamine are widely used in the food industry,cosmetics industry and pharmaceutical industry.With the development of the biological industry,the production method of glucosamine has been changed from the traditional acid hydrolysis chitin method to the microbial fermentation method.The article introduces the genetic engineering techniques and rational design methods of metabolic pathways used in the production of glucosamine by microbial fermentation in recent years.The production method and yield of glucosamine are discussed,which has certain guiding significance for the further production of glucosamine.

关 键 词：氨基葡萄糖 乙酰氨基葡萄糖 代谢途径 基因工程 

分 类 号：Q786[生物学—分子生物学]