ApoE基因多态性对急性缺血性脑卒中患者他汀疗效的影响  

Impacts of ApoE gene polymorphism on therapeutic efficacy of statin in patients with acute ischemic stroke

作　　者：王婵娟 郝志敏[1] 熊三军[1] 张伟兰 WANG Chanjuan;HAO Zhimin;XIONG Sanjun;ZHANG Weilan(Department of General Medicine,South Branch of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 201499,China)

机构地区：[1]上海交通大学附属第六人民医院南院全科医学科,上海201499

出　　处：《中国医药科学》2020年第23期230-232,共3页China Medicine And Pharmacy

摘　　要：目的探究ApoE基因多态性对急性缺血性脑卒中患者口服阿托伐他汀降脂效果的影响。方法选取2016年1~12月奉贤区中心医院急性缺血性脑卒中合并高脂血症的患者共300例,均予以阿托伐他汀20mg治疗6周,比较治疗前后患者血液中三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的含量变化,并分别测定入组患者ApoE基因型,分析ApoE基因多态性对患者血液中血脂水平的影响。结果治疗前基因型为E3/3的患者与基因型为E3/4的患者血脂水平(TG、TC、LDL-C)比较,差异无统计学意义(P> 0.05),治疗后两组血脂水平比较,差异有统计学意义(P <0.05)。结论 ApoE基因多态性影响急性缺血性脑卒合并高脂血症患者降脂效果。Objective To investigate the impacts of ApoE gene polymorphism on lipid-lowering efficacy of oral atorvastatin in patients with acute ischemic stroke. Methods A total of 300 patients with acute ischemic stroke complicated with hyperlipidemia admitted to Shanghai Fengxian District Central Hospital from January to December 2016 were all treated with atorvastatin 20 mg for 6 weeks. The content changes of TG, TC and LDL-C in patients’ blood before and after treatment were compared, the ApoE genotypes of grouped patients were determined respectively, the influence of ApoE gene polymorphism on blood lipid levels and was analyzed. Results There was no statistically significant difference in blood lipid levels(TG, TC, LDL-C) between patients with genotype E3/3 and those with genotype E3/4 before treatment(P > 0.05). After treatment, there were statistically significant differences in blood lipid levels between the two groups(P < 0.05). Conclusion ApoE gene polymorphism impacts the lipid-lowering efficacy in patients with acute ischemic stroke complicated with hyperlipidemia.

关 键 词：APOE基因多态性 高脂血症 阿托伐他汀 急性缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]