Strongyloidiasis in Ethiopia:systematic review on risk factors,diagnosis,prevalence and clinical outcomes  

作　　者：Yitagele Terefe Kirstin Ross Harriet Whiley 

机构地区：[1]College of Veterinary Medicine,Haramaya University,P.O.Box 138,Dire Dawa,Ethiopia [2]Foodborne Pathogen Diagnosis Research Laboratory,Haramaya University,P.O.Box 138,Dire Dawa,Ethiopia [3]Environmental Health,College of Science and Engineering,Flinders University,GPO Box 2100,Adelaide,South Australia 5001,Australia

出　　处：《Infectious Diseases of Poverty》2019年第3期32-42,共11页贫困所致传染病（英文）

摘　　要：Background:Strongyloidiasis is a gastrointestinal infection caused by the parasitic nematode Strongyloides stercorolis.It is estimated to infea up to 370 million people globally and is predominately found in tropical and subtropical areas of socioeconomic disadvantage.Main body:This systematic literature review identified studies published in the last ten years on the risk factors,diagnosis,prevalence and/or clinical outcomes of strongyloidiasis in Ethiopia.The prevalence of 5.stercoralis ranged from 0.2 to 11.1%in adults,0.3%to 20.7%in children,1.5%to 17.3%in HIV positive adults and 5%in HIV positive children.The identified studies primarily used microscopy based techniques that potentially underestimated the prevalence four fold compared with serology and PCR.Strongyloidiasis in children presents a particularly significant issue in Ethiopia as children often presented with anemia,which is associated with impaired mental and cognitive development.The most significant risk factor for strongyloidiasis was HIV status and although other risk factors were identified for helminth infections,none were statistically significant for 5.stercoralis specifically.Several studies detected 5.stercoralis in dogs and non-biting cyclorrhaphan flies.However,future research is needed to explore the role of these reservoirs in disease transmission.Conclusions:This review demonstrated that strongyloidiasis is an overlooked and neglected disease in Ethiopia.There is a need for a systematic approach using a combination of molecular and serology based diagnostic methods to ascertain the true incidence and burden of strongyloidiasis in Ethiopia.Further research is also needed to break the cycle of transmission by identifying environmental reservoirs,risk factors and exploring the potential for zoonotic transfer.

关 键 词：Neglected tropical disease Soil transmitted helminth Public health Strongyloides stercoralis AIDS HIV ANEMIA 

分 类 号：R73[医药卫生—肿瘤]